Facile Synthesis and Studies of 1,5-Benzothiazepine-2-carboxylic Acids
Seema Pant
, Pushpa Godwal , Radheshyam Kasana , Gajendra Singh Shekhawat , Chandra Bhushan Jain
β-benzoyl acrylic acid, 1,5-benzothiazepine-2-carboxylic acids, Staphylococcus aureus, Escherichia coli, Candida albicans
A series of 8-substituted-2,3-dihydro-1,5-benzothiazepine-2-carboxylic acids were synthesized by one-pot reactions of six 5-substituted-2-amino benzenethiols, the substitutes being fluoro, chloro, bromo, methyl, methoxy and ethoxy; and substituted β -benzoyl acrylic acid in ethanol utilizing glacial acetic acid as catalyst in 59-85% yields. The structures of compounds were characterized by FT-IR, NMR, and elemental analysis. Antimicrobial activities of these compounds were determined by using paper disc method against the gram-positive and gram-negative bacteria, Staphylococcus aureus and Escherichia coli respectively; and against the fungus, Candida albicans.
"Facile Synthesis and Studies of 1,5-Benzothiazepine-2-carboxylic Acids", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.7, Issue 12, page no.1206 - 1209, December-2022, Available :https://ijsdr.org/papers/IJSDR2212196.pdf
Volume 7
Issue 12,
December-2022
Pages : 1206 - 1209
Paper Reg. ID: IJSDR_203316
Published Paper Id: IJSDR2212196
Downloads: 000347276
Research Area: Physics
Country: Jaipur, Rajasthan, India
ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: IJSDR(IJ Publication) Janvi Wave
