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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | An overview on Adverse drug reactions (ADR) and its biomarkers |
| Authors Name: | Mr Basharat Nawaz , Mr. Mohd Razi |
| Unique Id: | IJSDR2302144 |
| Published In: | Volume 8 Issue 2, February-2023 |
| Abstract: | Adverse drug reactions (ADR) are a significant public health issue for both individuals and society. In developed nations, adverse drug reactions (ADRs) are among the top 10 leading causes of illness and death. ADRs are a public health issue though since they cause 5- 10% of hospitalizations and lengthen hospital stays . ADRs are between the fourth and sixth most common causes of death in some nations. Factors contributing to adverse drug reactions are age, sex, polypharmacy, pharmacogenetics, previous exposure etc. ADRs are classified into various categories depending upon their effect. Scales specifically designed for the identification of an ADR which includes Naranjo Scale Development,The WHO-UMC causality assessment system,Hartwig’s Severity Assessment Scale. . Adverse drug reactions also represent a financial burden to both healthcare providers and the pharmaceutical industry. Thus, a number of stakeholders would benefit from development of new, robust biomarkers for the prediction, diagnosis, and prognostication of adverse drug reactions. There has been significant recent progress in identifying predictive genomic biomarkers with the potential to be used in clinical settings to reduce the burden of adverse drug reactions. These have included biomarkers that can be used to alter drug dose (for example, Thiopurine methyltransferase (TPMT) and azathi oprine dose) and drug choice. The latter have in particular included human leukocyte anti gen (HLA) biomarkers which identify susceptibility to immune-mediated injuries to major organs such as skin, liver, and bone marrow from a variety of drugs. |
| Keywords: | Adverse drug reactions, prognostication, pharmacogenomics, biomarkers, human leukocyte antigen. |
| Cite Article: | "An overview on Adverse drug reactions (ADR) and its biomarkers", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 2, page no.824 - 841, February-2023, Available :http://www.ijsdr.org/papers/IJSDR2302144.pdf |
| Downloads: | 000338719 |
| Publication Details: | Published Paper ID: IJSDR2302144 Registration ID:204168 Published In: Volume 8 Issue 2, February-2023 DOI (Digital Object Identifier): Page No: 824 - 841 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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