Association between renal dysfunction markers and Creatine Kinase levels in Hypothyroidism.
Keywords: Creatinine, creatinine clearance, cystatin C, eGFR, hypothyroidism, renal dysfunction, myopathy, thyroid hormone, total creatine kinase.
Hypothyroidism is one of the most common endocrine disorders in clinical practice. It can affect the kidney function through various mechanisms, such as decreased cardiac output, increased vascular resistance, intrarenal vasoconstriction, reduced production and activity of hormones that regulate blood pressure and fluid balance, and altered kidney structure and feedback. Hypothyroidism can reduce renal plasma flow, glomerular filtration rate, and glomerular transcapillary pressure, which are important for kidney function. Hypothyroid myopathy is a common clinical feature in patients with hypothyroidism. The study was taken up to determine the influence of thyroid hormone on renal dysfunction markers, serum creatinine and cystatin C and on myopathy marker total creatine kinase levels and to evaluate the association between these dysfunction markers in hypothyroid cases. Serum T3, T4, TSH, Total Creatine Kinase, Cystatin C and Creatinine levels were estimated. Creatinine Clearance was calculated by using the Cockcroft-Gault formula and eGFR by using the MDRD formula. The elevation of serum creatinine in the study may be attributed to an increase in total creatine kinase levels which may be due to hypothyroid myopathy or decreased clearance by the kidneys. In contrast to creatinine concentrations, Cystatin C levels are lower in the hypothyroid cases suggesting a paradoxical relationship between them, though both are renal dysfunction markers. Hence interpretation of Cystatin C must be cautiously done in hypothyroidism.
"Association between renal dysfunction markers and Creatine Kinase levels in Hypothyroidism.", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.8, Issue 3, page no.242 - 247, March-2023, Available :https://ijsdr.org/papers/IJSDR2303038.pdf
Volume 8
Issue 3,
March-2023
Pages : 242 - 247
Paper Reg. ID: IJSDR_204174
Published Paper Id: IJSDR2303038
Downloads: 000347256
Research Area: Medical Science
Country: Bangalore, Karnataka, India
ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: IJSDR(IJ Publication) Janvi Wave
