INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016
open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15
Starting with 8-hydroxy quinoline, ten (E)-1-(8-hydroxyquinolin-7-yl)-3-phenylprop-2-en-1 derivatives were created via aldol condensation of substituted benzaldehydes with quinoline chalcones. For anti-asthmatic activity, molecular docking studies were performed on PDE 4 enzyme. Docking studies for anti-asthmatic activity show that compounds 2, 5, and 9 have significant binding interactions with the PDE 4 enzyme. According to studies, replacing the electron withdrawing and electron donating substitutions at the phenyl ring has good anti-asthmatic efficacy. Hence, it is concluded that the synthesized compounds have potent analgesic and anti-asthmatic properties.
Keywords:
3262
Cite Article:
"Focused on In-silico, Design , synthesis & evaluation of 8-hydroxyquinoline based nucleus covering prominent target PDE4 as anti-asthmatic agents", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 3, page no.690 - 695, March-2023, Available :http://www.ijsdr.org/papers/IJSDR2303111.pdf
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Publication Details:
Published Paper ID: IJSDR2303111
Registration ID:204509
Published In: Volume 8 Issue 3, March-2023
DOI (Digital Object Identifier):
Page No: 690 - 695
Publisher: IJSDR | www.ijsdr.org
ISSN Number: 2455-2631
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