Pharmacological Evaluation of Solanum Nigrum Leaves extract for its Memory enhancing activity
Ankita Raghuraj Pandey
, Dr. Rajesh Mandade , Prof. R. K. Kadam
Solanum Nigrum, Scopolamine, Piracetam, Memory Enhancement, amnesia
In the traditional system of medicine, the Leaves and berries of Solanum Nigrum have been employed clinically for centuries for their anti-inflammatory, antiulcer, antimicrobial and anxiolytic activities. The present study was undertaken to investigate the effects of Solanum Nigrum (popularly known as Blackberry) on learning and memory in mice. Elevated plus-maze and Water Morris maze were employed to test learning and memory. Two doses (100 and 200mg/kg p.o.) of Methanolic extract of Solanum Nigrum Leaves were administered for 7 successive days in separate groups of animals. The dose of 200 mg/kg of the methanolic extract of Blackberry significantly improved learning and memory of mice. Furthermore, this dose significantly reversed the amnesia induced by Piracetam (200 mg/kg i.p.) and scopolamine (0.1 mg/kg i.p.). Anti-inflammatory and antioxidant properties of Blackberry may be contributing favourably to the memory enhancement effect. Since scopolamine-induced amnesia was reversed by Blackberry, it is possible that the beneficial effect on learning and memory was due to facilitation of cholinergic-transmission in mouse brain. However, further studies are necessitated to identify the exact mechanism of action. In the present investigation, Solanum Nigrum has shown promise as a memory enhancing agent in all the laboratory models employed
"Pharmacological Evaluation of Solanum Nigrum Leaves extract for its Memory enhancing activity", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.8, Issue 5, page no.1342 - 1348, May-2023, Available :https://ijsdr.org/papers/IJSDR2305214.pdf
Volume 8
Issue 5,
May-2023
Pages : 1342 - 1348
Paper Reg. ID: IJSDR_206542
Published Paper Id: IJSDR2305214
Downloads: 000347226
Research Area: Science
Country: Yavatmal , Maharashtra , India
ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: IJSDR(IJ Publication) Janvi Wave
