|
INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
Imp Links for Author
Imp Links for Reviewer
Research Area
Subscribe IJSDR
Visitor Counter
Copyright Infringement Claims
Indexing Partner
|
Published Paper Details
|
|
| Paper Title: | Comparative in-vitro assessment of five Amlodipine Tablets marketed in Tripoli Libya |
| Authors Name: | TAMADER Y. ELGHNIMI , NARIMAN A. ELHABROUSH , GHADA M. ALGOHMACY |
| Unique Id: | IJSDR2306003 |
| Published In: | Volume 8 Issue 6, June-2023 |
| Abstract: | Amlodipine belongs to a group of medicines called calcium-channel blockers, used to treat high blood pressure [hypertension] or certain type of chest pain (angina), In patients with high blood pressure amlodipine works by relaxing blood vessels, so that blood passes through them more easily, In patients with angina amlodipine works by improving blood supply to the heart muscle which then receives more oxygen and as result chest pain is prevented. The availability of several brands of Amlodipine tablets in Libyan pharmacies today places health practitioners and a pharmacist in a problem of drug substitution in case of a particular brand is not available. The main purpose of this study was to evaluate the pharmaceutical properties of some commercial amlodipine 5mg tablets available in Tripoli Libya. Five different brands of amlodipine tablets were purchased from private pharmacies, with different price ranges, produced by various international pharmaceutical companies. Physicochemical properties of these tablets were assessed using official and unofficial quality control tests prescribed in different Pharmacopoeia included evaluation of appearance observation, hardness, thickness, diameter, friability, Content uniformity, weight variation, disintegration, dissolution as well as identification test by IR was conducted. The entire selected brands complied with the official test as prescribed by the United States Pharmacopeia standers and British Pharmacopeia Standers except brand B and E show only 80% and 85% respectively which is less percentage of the labeled amount of amlodipine active ingredient which should be within the acceptable range of 90-110% of the labeled amount. Results of dissolution test are all within the acceptable range of not less than 75% of the labeled amount of dissolved amlodipine. It can be concluded that brand A, C and D could be regarded as bioequivalent and therefore can be interchanged in the clinical practice; this sort of study is good indicator for the evaluation of the idealness of commercial products and showed the importance of post marketing investigation for the drugs imported and distributed in Libya. |
| Keywords: | Amlodipine tablets, Evaluation, Bioequivalence, Quality control, Generic drugs. |
| Cite Article: | "Comparative in-vitro assessment of five Amlodipine Tablets marketed in Tripoli Libya ", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 6, page no.16 - 22, June-2023, Available :http://www.ijsdr.org/papers/IJSDR2306003.pdf |
| Downloads: | 000337352 |
| Publication Details: | Published Paper ID: IJSDR2306003 Registration ID:206906 Published In: Volume 8 Issue 6, June-2023 DOI (Digital Object Identifier): Page No: 16 - 22 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
|
Click Here to Download This Article |
|
| Article Preview | |
|
|
|
Major Indexing from www.ijsdr.org
| Google Scholar | ResearcherID Thomson Reuters | Mendeley : reference manager | Academia.edu |
| arXiv.org : cornell university library | Research Gate | CiteSeerX | DOAJ : Directory of Open Access Journals |
| DRJI | Index Copernicus International | Scribd | DocStoc |
Track Paper
Important Links
Conference Proposal
ISSN
 |
 |
DOI (A digital object identifier)
  Providing A digital object identifier by DOI How to GET DOI and Hard Copy Related |
Open Access License Policy
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
|
 |
 |
 |
Social Media
Indexing Partner |
|||
| Copyright © 2024 - All Rights Reserved - IJSDR | |||
Facebook Twitter Instagram LinkedIn