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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Lambert eaton syndrome; a rare autoimmune disorder |
| Authors Name: | Dr. Tanya Wadhwa , Dr. Ayush Pandey |
| Unique Id: | IJSDR2306084 |
| Published In: | Volume 8 Issue 6, June-2023 |
| Abstract: | Lambert-Eaton syndrome (LES) or Lambert-Eaton myasthenic syndrome (LEMS), is a rare autoimmune disorder characterized by muscle weakness and impaired neuromuscular transmission. The case report being presented is of a 56-year-old female patient who complained of progressive muscle weakness, and autonomic dysfunction. The patient’s symptoms posed a diagnostic challenge due to their overlapping features with other neuromuscular {myasthenia gravis} and autoimmune conditions. However, thorough clinical evaluation, electromyography (EMG), and serological testing, including the detection of P/Q-type voltage-gated calcium channel antibodies led to a confirmed diagnosis of LES. Management of this patient involved a multidisciplinary approach, involving neurologists and oncologists. Treatment plan focused on symptomatic relief and immunomodulatory therapy. The patient underwent physical therapy, respiratory assistance, and pharmacological interventions to manage symptoms associated with muscle weakness and autonomic dysfunction. Additionally, immunotherapy with intravenous immunoglobulins (IVIG) and potassium channel blockers, such as 3,4-diaminopyridine (3,4-DAP), was administered. Despite initial challenges in the diagnosis and management of LES, the patient demonstrated a favorable response to treatment, with gradual improvement in muscle strength and autonomic symptoms over time. Regular follow-up visits, along with adjustment to the treatment regimen, are essential to maintain disease stability and optimize the patient's quality of life. This case report highlights the importance of early recognition and accurate diagnosis of LES, particularly in patients with a history of malignancy. It emphasizes the significance of a comprehensive evaluation, including clinical assessment, electrophysiological studies, and serological testing, to differentiate LES from other neuromuscular disorders. Timely initiation of appropriate treatment strategies, encompassing both symptomatic relief and immunomodulatory therapy, can significantly improve patient outcomes and enhance their overall well-being. Further research and clinical studies are warranted to refine diagnostic criteria and optimize treatment protocols for Lambert-Eaton syndrome. |
| Keywords: | Autoimmune P/Q type VGCC antibodies CALES NCALES CMAP amplitude IVIG 3, 4 DAP |
| Cite Article: | "Lambert eaton syndrome; a rare autoimmune disorder", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 6, page no.578 - 579, June-2023, Available :http://www.ijsdr.org/papers/IJSDR2306084.pdf |
| Downloads: | 000337351 |
| Publication Details: | Published Paper ID: IJSDR2306084 Registration ID:207144 Published In: Volume 8 Issue 6, June-2023 DOI (Digital Object Identifier): Page No: 578 - 579 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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