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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | IMPACT OF IRON DEFICENCY AND APPROACH TO IRON ADMINISTRATION IN PREGNANCY |
| Authors Name: | Anunasrin.M , Venkateswaramurthy.N |
| Unique Id: | IJSDR2306129 |
| Published In: | Volume 8 Issue 6, June-2023 |
| Abstract: | Anaemia, which is defined as a haemoglobin (Hb) concentration no lower than 10 g/dL at term, affects virtually all pregnancies, and in the majority of instances, it is induced by a physiological process rather than indicating a deficient status or underlying hematologic illness. The amount of iron in the human body is carefully controlled and is typically kept at around 40 mg/kg for women and 50 mg/kg for males. Iron balance is regulated at the levels of iron absorption by enterocytes in the duodenum and of iron mobilisation from liver parenchyma and macrophages because humans are unable to eliminate excess iron in a controlled manner. A uncommon recessive illness known as iron resistant iron deficiency anaemia (IRIDA) is characterised by hypochromic microcytic anaemia, poor transferrin saturation, and abnormally normal or high hepcidin levels. Matriptase-2, a type II serine protease, is encoded by the TMPRSS6 gene, which is the source of its mutations. There is controversy about whether or not certain individuals with a phenotype of refractory iron deficiency who have a single mutant allele of TMPRSS6 should be classified as having IRIDA. It is possible to imagine a range of situations, from the typical form of severe IRIDA caused by homozygous or compound heterozygous TMPRSS6 mutations to enhanced vulnerability to iron shortage brought on by single mutations/polymorphic alterations. Pregnancy-related physiologic anaemia is a dilutional process brought on by an increase in plasma volume. Plasma volume rises from 25% to 80% during a typical pregnancy. The increase starts at 6 weeks into the pregnancy and lasts until 24 weeks, after which there is a slower increase. The weight of the foetus is directly related to the rise in plasma volume. In women who do not take additional iron, the erythrocyte mass also rises during pregnancy, increasing by 180–250 ml, or 10%–20% more than usual. Depleted iron reserves are 49 by iron deficiency (ID). The absence of stainable reticuloendothelial iron on a bone marrow specimen is the "gold standard" for identifying ID, although in clinical practise, it is typically identified by substitute laboratory indicators as a low serum ferritin or a reduced percentage of transferrin saturation by iron. The majority of expectant individuals can take oral iron, especially when it is administered once daily or on an irregular basis. However, intravenous iron treatment is secure and efficient if the patient is refractory to oral iron or unable or unable to consume iron orally. |
| Keywords: | Iron, pregnancy, haemoglobin, anaemia |
| Cite Article: | "IMPACT OF IRON DEFICENCY AND APPROACH TO IRON ADMINISTRATION IN PREGNANCY", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 6, page no.898 - 904, June-2023, Available :http://www.ijsdr.org/papers/IJSDR2306129.pdf |
| Downloads: | 000337351 |
| Publication Details: | Published Paper ID: IJSDR2306129 Registration ID:207202 Published In: Volume 8 Issue 6, June-2023 DOI (Digital Object Identifier): Page No: 898 - 904 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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