INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016
open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15
Amit Kumar Patel
, P. M. Phole , M. S. Charde , R. D. Chakole , Kalpesh Narayan Girap
Unique Id:
IJSDR2306136
Published In:
Volume 8 Issue 6, June-2023
Abstract:
Studies on forced degradation involve the breakdown of novel pharmacological substances and drug products under conditions that are more demanding than accelerated conditions. These investigations demonstrate the molecule's chemical stability, which makes it easier to create stable formulations with proper storage conditions. According to ICH recommendations, some factors might cause degradation, such as light, oxidation, dry heat, acidic or basic environments, hydrolysis, etc. The forced deterioration experiments are best illustrated by ICH Q1A, QIB, and Q2B. The strategic philosophies and developments in forced degradation studies are surveyed in this article.
Keywords:
Degradation, Stability, Safety, ICH guidelines
Cite Article:
"Force Degradation for Pharmaceuticals: A Review", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 6, page no.954 - 959, June-2023, Available :http://www.ijsdr.org/papers/IJSDR2306136.pdf
Downloads:
000337351
Publication Details:
Published Paper ID: IJSDR2306136
Registration ID:207238
Published In: Volume 8 Issue 6, June-2023
DOI (Digital Object Identifier):
Page No: 954 - 959
Publisher: IJSDR | www.ijsdr.org
ISSN Number: 2455-2631
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