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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | An Insight into the Cellular and Molecular Mechanisms Underlying the Metastasis of Breast Cancer |
| Authors Name: | Pratyasha Sarangi |
| Unique Id: | IJSDR2306148 |
| Published In: | Volume 8 Issue 6, June-2023 |
| Abstract: | Metastasis is defined as the phenomenon of invasion and migration of cancer cells away from the original tumor to nearby tissues and other organs. Cancer metastasis is a complicated process and is the most harmful feature of cancer. Breast cancer is the most prevalent malignancy of the world and accounts for majority of cancer-associated deaths among women worldwide. In breast cancer metastasis, the cells separate from the original breast tumor and travel to remote organs such as the brain, liver, lungs, and bones via blood vessels or lymph nodes. Moreover, the preferred metastatic location of the disseminated breast cancer cells depends on their specific clinical subtypes. 10%-15% of the total number of patients affected by breast cancer develop the aggressive form of the disease causing the tumor cells to migrate to distant organs within three years of developing the primary tumor. When compared to the primary tumor, metastatic breast cancer is quite diverse in characteristics making it tedious to assess the risk factors responsible for promoting metastasis and discover an efficient and effective treatment approach. However, the formation of micrometastases at remote sites after ten years of initial diagnosis is quite natural. Therefore, the need to understand the basics of the metastasis process of breast cancer arises. In this review, a narrative description of the cellular and molecular mechanisms of breast cancer metastasis along with the emerging options of different therapeutic measures is provided. |
| Keywords: | Breast cancer, Metastasis, Invasion, Angiogenesis, Circulating tumor cells. |
| Cite Article: | "An Insight into the Cellular and Molecular Mechanisms Underlying the Metastasis of Breast Cancer", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 6, page no.1037 - 1050, June-2023, Available :http://www.ijsdr.org/papers/IJSDR2306148.pdf |
| Downloads: | 000337351 |
| Publication Details: | Published Paper ID: IJSDR2306148 Registration ID:207266 Published In: Volume 8 Issue 6, June-2023 DOI (Digital Object Identifier): Page No: 1037 - 1050 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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