|
INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
Imp Links for Author
Imp Links for Reviewer
Research Area
Subscribe IJSDR
Visitor Counter
Copyright Infringement Claims
Indexing Partner
|
Published Paper Details
|
|
| Paper Title: | Repurposing and in- vitro evaluation of existing drug for the management of diabetes |
| Authors Name: | Apurva joshi , Kushagra dubey |
| Unique Id: | IJSDR2306256 |
| Published In: | Volume 8 Issue 6, June-2023 |
| Abstract: | Diabetes is one of the largest global public health concerns, imposing a heavy global burden on public health as well as socio-economic development. Diabetes is one of the top 10 causes of death globally. Individuals with diabetes have 2-3 fold risks of all-cause mortality. The global burden of diabetes has increased significantly in recent decades and will continue to soar in the next few decades. Patients suffering from diabetes has to take medications in the form of oral tablets or insulin injection. In case, if a patient suffers from more than one disease such as hypertension, cardiovascular disease, etc. along with diabetes, then the patient has to take multiple drugs for living a normal life. The consumption of multiple drugs on a daily basis causes non-compliance in the patients. To overcome this problems repurposing of drugs is helpful for the management of diabetes mellitus. Many drugs which are used for the treatment of some other disease or disorder, can show its usefulness in the management of diabetes mellitus. In this research work, 24 drugs have been docked with alpha-amylase to form a ligand-protein complex. The docking has been performed to obtain mol dock score which is compared with standard acarbose drug. 2 drugs namely Ketoconazole and Domperidone have been found to be compatible for the purpose of management of diabetes. |
| Keywords: | Molecular docking, repurposing, Ketoconazole, Domperidone, alpha-amylase, mol dock score |
| Cite Article: | "Repurposing and in- vitro evaluation of existing drug for the management of diabetes ", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 6, page no.1882 - 1888, June-2023, Available :http://www.ijsdr.org/papers/IJSDR2306256.pdf |
| Downloads: | 000337351 |
| Publication Details: | Published Paper ID: IJSDR2306256 Registration ID:207461 Published In: Volume 8 Issue 6, June-2023 DOI (Digital Object Identifier): Page No: 1882 - 1888 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
|
Click Here to Download This Article |
|
| Article Preview | |
|
|
|
Major Indexing from www.ijsdr.org
| Google Scholar | ResearcherID Thomson Reuters | Mendeley : reference manager | Academia.edu |
| arXiv.org : cornell university library | Research Gate | CiteSeerX | DOAJ : Directory of Open Access Journals |
| DRJI | Index Copernicus International | Scribd | DocStoc |
Track Paper
Important Links
Conference Proposal
ISSN
 |
 |
DOI (A digital object identifier)
  Providing A digital object identifier by DOI How to GET DOI and Hard Copy Related |
Open Access License Policy
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
|
 |
 |
 |
Social Media
Indexing Partner |
|||
| Copyright © 2024 - All Rights Reserved - IJSDR | |||
Facebook Twitter Instagram LinkedIn