Formulation and Evaluation of sustained release floating microbeads of ketoprofen

Rajan Sah , Keerthi H. S. , Shivanand K. Mutta , Sowmya T. P. , Pradeep Kumar Patel

Key Words:- Ketoprofen, Rheumatoid arthritis, ionotropic gelation, floating microbeads, Gastric residence time, Buoyancy.

Aim:The main intention of the present study is to develop the ideal floating microbeads of Ketoprofenfor prolongation of the gastric retention time in stomach and enhance the patient compliance in the treatment of pain. Objective:Ketoprofen is apropionic acid derivative, it reversibly inhibits cyclooxygenase-1 and 2 (COX-1&2) enzymes, resulting to decrease formation of prostaglandin precursors. The elimination half-life of Ketoprofen is 2.4hrs. In the latest research work the floating drug delivery system of Ketoprofen floating microbeads were prepared by using some polymers are sodium alginate, HPMC K100M, Carbopol 934, Methyl cellulose as a polymer and calcium carbonate used as gas forming agent. Method:The floating microbeads were prepared by ionotropic gelation technique. By the FTIR technique the compatibility of drug and polymers were compared. The prepared microbeads were evaluated for physical characterization floating lag time, swelling index, entrapment efficiency, buoyancy studies, invitro drug

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"Formulation and Evaluation of sustained release floating microbeads of ketoprofen ", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.8, Issue 7, page no.89 - 100, July-2023, Available :https://ijsdr.org/papers/IJSDR2307014.pdf

Volume 8 Issue 7, July-2023

Pages : 89 - 100

Paper Reg. ID: IJSDR_207561

Published Paper Id: IJSDR2307014

Downloads: 000347240

Research Area: Pharmacy

Country: Bangalore, Karnataka, India

Published Paper PDF: https://ijsdr.org/papers/IJSDR2307014

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR2307014

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJSDR(IJ Publication) Janvi Wave

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