Insilico design of dibenzazepine derivatives as GABA -A agonist
Rachel Mathew
, Anjana V S , Fathima A S , Amina A , Alfiya N
Convulsion, Insilico, Chemsketch, Docking, PyMOL, Carbamazepine, GABA-A
Convulsion is considered as the most common serious brain conditions. Surgery is the only way in the eradication of convulsion. This project aims at designing dibenzazepine derivatives as anticonvulsant agents by agonistic activity in GABA-A receptor. Different dibenzazepine derivatives were designed using ACD Lab Chemsketch12.0 software and their properties were predicted using Molinspiration software. The designed derivatives showing optimal physicochemical properties were selected for docking studies. The various methodology used in the study include random selection of drugs, ChemSketch for drawing 2D structure, docking using AutoDock program and visualising the output using PyMOL. The ligands which shows good binding score with GABA-A receptor were selected as anticonvulsant drugs and carbamazepine was selected as standard drug.
"Insilico design of dibenzazepine derivatives as GABA -A agonist", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.8, Issue 7, page no.146 - 154, July-2023, Available :https://ijsdr.org/papers/IJSDR2307021.pdf
Volume 8
Issue 7,
July-2023
Pages : 146 - 154
Paper Reg. ID: IJSDR_207579
Published Paper Id: IJSDR2307021
Downloads: 000347232
Research Area: Pharmacy
Country: Trivandrum, Kerala, India
ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: IJSDR(IJ Publication) Janvi Wave
