Method development, validation and rapid determination of Cetirizine Hydrochloride drug by chromatographic technique.
Anil Nishad
, Dr. Gayatri Barabde , Dr. Sushma Ambadekar , Dr. Amit Padelkar
A simple, sensitive, precise and accurate reverse phase liquid chromatographic method for the analysis of Cetirizine hydrochloride has been developed and validated. This method is used for the determination of compounds in commercial pharmaceutical products. The compounds were well separated on a C18 column [ Inertsil C18, 5µm, 150 x 4.6 mm] utilizing a mobile phase consisting of acetonitrile: phosphate buffer (45:55 (v/v), pH7.0) at a flow rate of 1.0 ml/min with UV detection at 230 nm. The retention time of Cetirizine hydrochloride was found to be 3.11minute.With this method linearity was observed (Correlation coefficient=0.999). According to the validation results, the proposed method was found to be specific, accurate, precise and rapid. Hence the same can be applied to the quantitative analysis of tablets containing Cetirizine hydrochloride.
"Method development, validation and rapid determination of Cetirizine Hydrochloride drug by chromatographic technique.", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.8, Issue 7, page no.642 - 648, July-2023, Available :https://ijsdr.org/papers/IJSDR2307094.pdf
Volume 8
Issue 7,
July-2023
Pages : 642 - 648
Paper Reg. ID: IJSDR_207760
Published Paper Id: IJSDR2307094
Downloads: 000347270
Research Area: Chemistry
Country: Mumbai, Maharashtra, India
ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: IJSDR(IJ Publication) Janvi Wave
