Metho development of umbralisib by using RP HPLC
K Hima Bindu
, Dr. K. Venkataramana , K. Kalyan Chakravarthi
A simple, rapid, precise, sensitive and reproducible reverse phase high performance liquid chromatography (RP-HPLC) method has been developed for the quantitative analysis of Umbralisib in pharmaceutical dosage form. Chromatographic separation of Umbralisib was achieved on Waters Alliance-e2695, by using Waters X-Terra RP-18 Column (150x4.6mm, 3.5µ) column and the mobile phase containing ACN and Ammonium formate pH-3.0/OPA in the ratio of 50:50% v/v. The flow rate was 1.0 ml/min; detection was carried out by absorption at 225nm using a photodiode array detector at ambient temperature. The number of theoretical plates and tailing factor for Umbralisib were NLT 2000 and should not more than 2 respectively. % Relative standard deviation of peak areas of all measurements always less than 2.0. The proposed method was validated according to ICH guidelines. The method was found to be simple, economical, suitable, precise, accurate & robust method for quantitative analysis of Umbralisib.
"Metho development of umbralisib by using RP HPLC", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.8, Issue 7, page no.745 - 750, July-2023, Available :https://ijsdr.org/papers/IJSDR2307107.pdf
Volume 8
Issue 7,
July-2023
Pages : 745 - 750
Paper Reg. ID: IJSDR_207681
Published Paper Id: IJSDR2307107
Downloads: 000347315
Research Area: Pharmacy
Country: guntur (District), Andhra Pradesh, India
ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: IJSDR(IJ Publication) Janvi Wave
