PROCESS VALIDATION OF DOMPERIDONE SUSTAINED RELEASE AND PANTOPRAZOLE ENTERIC COATED TABLET IN TABLET FORMULATION
Sunita Raina
, Gulbahar , Saurabh Pant
Direct compression, Pantoprazole, Proton pump inhibitor
A proton pump inhibitor that is a member of the benzimidazole family, pantoprazole was manufactured using the direct compression method, microcrystalline cellulose as filler, mannitol and dicalcium phosphate as diluents, croscarmellose sodium as a disintegrating agent, magnesium stearate as a glidant, and talc as a lubricant. Since it involves fewer unit operations than wet granulation, direct compression is more cost-effective. As a result, the cost of producing tablets will be lower since there will be less equipment, less power usage, less space, less time, and less labour. The manufactured tablets were tested for uniformity of drug content, weight variation, friability, and hardness, and it was discovered that the results meet official standards. The produced tablets were coated using a dip coating technique and an enteric coating polymer, such as cellulose acetate phthalate. Using an acidic buffer pH of 1.2 and a phosphate buffer pH of 6.8, the in vitro release was investigated. The best batches were those that had been prepared, with the hardness, drug content, time till disintegration, and cumulative drug release % starting after 120 minutes and reaching 99.72 after 180 minutes. Studies on stability showed that the created tablets maintained their medicinal qualities for three months at room temperature and at 40°C and 75 percent relative humidity
"PROCESS VALIDATION OF DOMPERIDONE SUSTAINED RELEASE AND PANTOPRAZOLE ENTERIC COATED TABLET IN TABLET FORMULATION", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.8, Issue 7, page no.993 - 1001, July-2023, Available :https://ijsdr.org/papers/IJSDR2307149.pdf
Volume 8
Issue 7,
July-2023
Pages : 993 - 1001
Paper Reg. ID: IJSDR_207904
Published Paper Id: IJSDR2307149
Downloads: 000347371
Research Area: Pharmacy
Country: Dehradun, UTTARAKHAND, India
ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: IJSDR(IJ Publication) Janvi Wave
