DEVELOPMENT AND VALIDATION OF UV SPECTROSCOPIC METHOD FOR SIMULTANEOUS ESTIMATION OF FLUTICASONE FUROATE AND VILANTEROL IN PHARMACEUTICAL FORMULATIONS

Ashwini Pawar , Sagar Kale , Sanket Patil , Kaufiya Sayyad , Ranjeet Vibhute

Fluticasone furoate, Vilanterol, UV-visible Spectrometry

The present study describes a new, simple, precise, accurate, reproducible, and efficient UV spectroscopic method that was developed and validated for simultaneous estimation of fluticasone furoate and Vilanterol in pure and pharmaceutical dosage form. The absorbance of fluticasone furoate and Vilanterol was found to be 242nm and 259nm, respectively. Calibration curves of fluticasone furoate and Vilanterol were found to be linear in the concentration ranges of 8-12µg/mL and 2-3µg/mL with their correlation coefficient values (R2) 0.9987 and 0.9992, respectively. LOD and LOQ were found to be 0.68µg/mL and 2.07µg/mL for Fluticasone Furoate and 0.13µg/mL and 0.40µg/mL for Vilanterol, respectively. In the precision study, the % RSD value was found within limits (RSD < 2%). The percentage recovery at various concentration levels varied from 99.73 to 100.60% for Fluticasone Furoate and 101.80 to 100.66% for Vilanterol, respectively. The proposed method can be applied successfully for the simultaneous estimation of fluticasone furoate and Vilanterol in pure and pharmaceutical dosage form. In this method simultaneous equation method was applied to find assay of both drugs in pharmaceutical dosage form. The methods were validated in accordance with ICH Q2 guidelines.

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"DEVELOPMENT AND VALIDATION OF UV SPECTROSCOPIC METHOD FOR SIMULTANEOUS ESTIMATION OF FLUTICASONE FUROATE AND VILANTEROL IN PHARMACEUTICAL FORMULATIONS", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.8, Issue 7, page no.1337 - 1345, July-2023, Available :https://ijsdr.org/papers/IJSDR2307201.pdf

Volume 8 Issue 7, July-2023

Pages : 1337 - 1345

Paper Reg. ID: IJSDR_208029

Published Paper Id: IJSDR2307201

Downloads: 000347343

Research Area: Pharmacy

Country: Latur, Maharashtra, India

Published Paper PDF: https://ijsdr.org/papers/IJSDR2307201

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR2307201

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJSDR(IJ Publication) Janvi Wave

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