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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | DEVELOPMENT OF ABELMASCHUS ESCULENTUS L BASED NANOPARTICLES FOR PERMEABILITY ENHANCEMENT OF RIZATRIPTAN BENZOATE VIA NASOPULMONARY ROUTE. |
| Authors Name: | Amulya Jindal , Mainuddin , Dhananjay Taumar , Khushi Goel , Deepak Tomar |
| Unique Id: | IJSDR2308013 |
| Published In: | Volume 8 Issue 8, August-2023 |
| Abstract: | Rizatriptan benzoate (RB), a selective 5-hydroxytryptamine 1B/1D (5-HT1B/1D) receptor agonist has only 40–50% bioavailability orally presystemic metabolized by the enzyme monoamine oxidase-A (MAO-A). This bioavailability issue can be solved with improved AUC brain ratios through the development of nose-to-brain delivery systems. Nose-to-brain delivery of RB nanoparticles (NP) is investigated to enhance its bioavailability through avoidance of the presystemic first-pass effect. Polymeric NP from Abelmaschus esculentus L (AE) was prepared by crosslinking method. NP possesses size range of 50-300 nm for RB. The pH was found to be 5.99±0.54 results a polysaccharide solution within the physiological range, hence it is non-irritating to the biological mucosa. Previously surface tension and swelling index demonstrated its mucoadhesive uses. The natural polysaccharide derived from AE can be utilized for the fabrication of NP using the emulsification method by using distilled water, drug, castor oil, and Span 80 (5% v/v). The thermal behavior, particle size (nm), shape and surface morphology, drug encapsulation effectiveness, drug loading, and ex-vivo permeation studies of NP were all characterized. Finally, the in-vivo biodistribution of RB in the brain was investigated using the brain homogenization method by adopting the HPLC method to estimate the drug in male Wistar albino rats. Drug-loaded NP DSC thermograms show that all drug molecules have been evenly distributed throughout the polymer matrix. The mean particle size of NP ranges between 256 and 826 nm and increasing the concentration of polymer resultantly increased the particle size of NP. The formulation’s SEM analyses were spherical with variable surface roughness. Ex-vivo permeation studies show a control release profile for RB improved for intranasal delivery. It concludes that Abelmaschus esculentus L polysaccharide and RB can be implemented in the preparation of NP for nose-to-brain delivery. |
| Keywords: | Rizatriptan benzoate, Abelmaschus esculentus L, Nanoparticles, Permeability enhancement, Nasal delivery |
| Cite Article: | "DEVELOPMENT OF ABELMASCHUS ESCULENTUS L BASED NANOPARTICLES FOR PERMEABILITY ENHANCEMENT OF RIZATRIPTAN BENZOATE VIA NASOPULMONARY ROUTE.", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 8, page no.81 - 91, August-2023, Available :http://www.ijsdr.org/papers/IJSDR2308013.pdf |
| Downloads: | 000338719 |
| Publication Details: | Published Paper ID: IJSDR2308013 Registration ID:208001 Published In: Volume 8 Issue 8, August-2023 DOI (Digital Object Identifier): Page No: 81 - 91 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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