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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Solubility enhancement of lurasidone hydrochloride by solid dispersion technique |
| Authors Name: | G.Rajalakshmi , Aarthi Sankar , Dr.R.Sundhararajan |
| Unique Id: | IJSDR2308098 |
| Published In: | Volume 8 Issue 8, August-2023 |
| Abstract: | Solid dispersion was most widely and successfully applied to improve the solubility, dissolution rates, and consequently the bioavailability of poorly soluble drugs. Lurasidone hydrochloride (LH) is a poorly water-soluble drug. It belongs to BCS class II. It is prescribed as an antipsychotic drug for the treatment of symptoms of mental disorders such as schizophrenia and bipolar disorder. The present study was planned to prepare and evaluate the solid dispersion (SD) of Lurasidone hydrochloride. Solid dispersion of Lurasidone hydrochloride (LH SD) was prepared using Vitamin E TPGS and Polyethylene glycol (PEG) 6000 as a carrier by Fusion method and using Cyclodextrin-B (CD-B) by the solvent evaporation method. The prepared SD was characterized and filled into hard gelatin capsules. The filled hard gelatin capsules were evaluated for weight variation, drug content, and disintegration time, and in-vitro dissolution study. The cumulative amount of drug release of LH: vitamin ETPGS in 1:3 ratio showed 99.31% at the end of 1 hour. Therefore, it can be concluded that the dissolution rate of the poorly soluble drug Lurasidone hydrochloride can be enhanced by formulating it into solid dispersion using water soluble carrier vitamin E TPGS. |
| Keywords: | Keywords: Solid dispersion, Lurasidone hydrochloride Vitamin E TPGS, Cyclodextrin-B, PEG-6000, solubility |
| Cite Article: | "Solubility enhancement of lurasidone hydrochloride by solid dispersion technique", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 8, page no.669 - 680, August-2023, Available :http://www.ijsdr.org/papers/IJSDR2308098.pdf |
| Downloads: | 000338719 |
| Publication Details: | Published Paper ID: IJSDR2308098 Registration ID:208217 Published In: Volume 8 Issue 8, August-2023 DOI (Digital Object Identifier): Page No: 669 - 680 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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