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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Anti-oxidant and Anti-hepatotoxic Activities of Taraxacum officinale Weber (Dandelion) |
| Authors Name: | Mohd Zafar , Dr. Bhanu P. S. Sagar , Dr. Amrita Singh , Snehil Singh , Abdul Hafeez |
| Unique Id: | IJSDR2308120 |
| Published In: | Volume 8 Issue 8, August-2023 |
| Abstract: | Herbal medicine is currently enjoying a revival in popularity in the west and in many parts of the world. Now a day, various herbal formulations / phyotoformulations are commercially available for the prevention and treatment of hepatotoxicity. Taraxacum officinale (dandelion) contains compounds with various medicinal activities. This dissertation work was an attempt to establish scientific protocols to perform pharmacological investigation / research on Taraxacum officinale for anti-hepatoxic effect against paracetamol. High amount of total phenolics and total flavonoid content were found in the EETOL Extract than EETOR Extract. In toxicity studies, mortality rates were zero percent and dandelion extracts possess wide safety margin and classified as Non-Toxic Constituent. Extracts caused slight change blood parameters whereas LFTs were not significantly altered. In anti-hepatotoxic pharmacological studies, PCM induced hepatoxicity by glutathione depletion, necrosis of hepatocytes, elevated levels LFTs with centilobular necrosis. EETOL extract produced remarkable anti-hepatotoxic activity with significant alleviation of LFTs and reddish coloration, normal anatomical architecture of the hepatocytes (reversal effects). Anti-hepatotoxic effects were comparatively lesser then standard Silymarin and pharmacodynamics includes membrane stabilization; inhibition of phopholipase A2; anti-inflammatory; anti-oxidant; attenuation of depletion of glutathione; and enhanced proteins synthesis. Further, in thiopentone sodium induced sleeping time analysis, reduction in sleeping time was recorded in dandelion EETOL extract treated animals when compared to toxic control animals. |
| Keywords: | Anti-oxidant, Anti-hepatotoxic, catalase, dandelion, glutathione, nitric acid, paracetamol, peroxidise, silymarin, superoxide dismutase, thiopentone sodium. |
| Cite Article: | "Anti-oxidant and Anti-hepatotoxic Activities of Taraxacum officinale Weber (Dandelion)", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 8, page no.818 - 829, August-2023, Available :http://www.ijsdr.org/papers/IJSDR2308120.pdf |
| Downloads: | 000338719 |
| Publication Details: | Published Paper ID: IJSDR2308120 Registration ID:208296 Published In: Volume 8 Issue 8, August-2023 DOI (Digital Object Identifier): Page No: 818 - 829 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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