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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Molecular docking studies on Anti-ulcer activity abd qualitative biochemical analysis of Gunmathukku kudineer -A siddha polyherbal formulation |
| Authors Name: | ADITHYA S R , ARYA A V , SUNDARARAJAN S |
| Unique Id: | IJSDR2308155 |
| Published In: | Volume 8 Issue 8, August-2023 |
| Abstract: | ABSTRACT: Background :Siddha system of medicine is the indigenous system of medicine practiced in south India especially in Tamilnadu. Gunmam (Peptic Ulcer) is one of the disease out of 4448 diseases mentioned in Siddha literatures.Yugi Muni has described about Gunmam in “Yugi Vaithiya Chinthamani’.Gunmam may be compared with Peptic Ulcer disease in modern aspect. Gunmathukku Kudineer is a polyherbal drug indicated for Gunmam which is mentioned in the Siddha Literature “Thanwanthiri Vaithiyakkummi-300.Aim: The aim of the study is to analyze the in-vitro anti ulcer potential and biochemical analysis of Gunmathukku Kudineer.Methodology: The present study was undertaken to evaluate anti-ulcer activity of Gunmathukku Kudineer by binding of phytocomponents with the core amino acids (LYS-445 and VAL-473, TYR-475) of the target by forming hydrogen bond will hinder the function of the enzyme H pylori Urease with PDB – 1E9Y. The enzyme urease catalyses the hydrolysis of urea to ammonia. Urease has been reported to be a prominent virulence determinant of H pylori in the pathogenesis of ulcer. Thereby phytocomponents which inhibit the target viral enzyme H pylori urease may act as a potential therapeutic agent for management of ulcer caused by H Pylori.Result: The study result concludes that Gunmathukku Kudineer has significant Anti-ulcer activity. |
| Keywords: | Keywords: Gunmam,Peptic Ulcer,Gumathukku kudineer,Anti-ulcer activity. |
| Cite Article: | "Molecular docking studies on Anti-ulcer activity abd qualitative biochemical analysis of Gunmathukku kudineer -A siddha polyherbal formulation", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 8, page no.1048 - 1052, August-2023, Available :http://www.ijsdr.org/papers/IJSDR2308155.pdf |
| Downloads: | 000338719 |
| Publication Details: | Published Paper ID: IJSDR2308155 Registration ID:208362 Published In: Volume 8 Issue 8, August-2023 DOI (Digital Object Identifier): Page No: 1048 - 1052 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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