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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Haemoprotective potential of Picrorhiza kurroa against radiation and mercury induced changes in mice. |
| Authors Name: | Monika Saini , MANISHA AGARWAL , ARCHANA PUROHIT , ARUNA CHAKRAWARTI , R.K. PUROHIT |
| Unique Id: | IJSDR2308170 |
| Published In: | Volume 8 Issue 8, August-2023 |
| Abstract: | Ionizing radiation (IR) has a sufficient amount of energy to induce physical symptomatology within minutes of exposure, appearing as the acute radiation syndrome (ARS). The prodromal phase of ARS includes nausea, vomiting, and fatigue. The quality of radiation, dose, and dose-rate are all contributing factors to the differential symptoms of ARS. These prodromal symptoms can be followed by dramatic decrease in peripheral blood cell counts, as hematopoietic cells represent a renewal system consisting of cells with fast division rates that are known to be sensitive to IR. Once in the bloodstream mercury go through catalase and peroxidase-mediated oxidation in the red blood cell and tissue and convert into inorganic mercuric mercury and mercurous mercury, a procedure restriction mercury absorption. High level showing to mercury make changes in the central nervous system, possible outcome in irritability, fatigue, behavioural change, tremors, headache, hearing and cognitive loss, dysarthria, in coordination, hallucination, death, hypertension and change in endothelial function. Picrorhiza kurroa widely used in traditional systems of medicine and have rendered significant radioprotection in both in vitro and in vivo model systems. Plants and their constituents with pharmacological activities that may be relevant to amelioration of radiation-mediated damage, including antiemetic, anti-inflammatory, antioxidant, cell proliferative, wound healing and haemopoietic stimulators are also discussed. In view of above, present study was planned to evaluate the radiation and mecury induced changes in mice and their protection by Picrorhiza kurroa. The animals were exposed to 2.5 Gy of gamma rays with or without mercuric chloride treatment. The more severe changes in the combined treatment group showing synergistic effects. The kutki treated groups showed less prominent changes and early recovery may be due to the protection provided by the drug. |
| Keywords: | radiation .mercury mice,picrorhiza,blood |
| Cite Article: | "Haemoprotective potential of Picrorhiza kurroa against radiation and mercury induced changes in mice.", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 8, page no.1159 - 1164, August-2023, Available :http://www.ijsdr.org/papers/IJSDR2308170.pdf |
| Downloads: | 000338719 |
| Publication Details: | Published Paper ID: IJSDR2308170 Registration ID:208406 Published In: Volume 8 Issue 8, August-2023 DOI (Digital Object Identifier): Page No: 1159 - 1164 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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