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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Drug Induced Hepatotoxicity and Hepatoprotective Drugs : A Review |
| Authors Name: | Inayat Ullah Khan , Mohd Zafar , Amrita Singh , Snehil Singh , Bhanu P. S. Sagar |
| Unique Id: | IJSDR2309058 |
| Published In: | Volume 8 Issue 9, September-2023 |
| Abstract: | Liver damage is a term for collection of conditions, diseases and infections that affect the cells, tissues, structures of function of hepatic cells. Hepatotoxicity is disorder which cause of mortality and morbidity due to environmental pollutants; hepatic cancer; alcoholic and intoxicants and other drug therapy. Drug-induced hepatotoxicity (DIH) / Drug-induced Liver injury (DILI) is the most common cause of acute hepatic failure. Drug-induced hepatotoxicity is a severe problem as it affects a huge population around throughout the globe, and it is the most highly cited reason for the failure of drugs. Hepatoprotection is of intense interest and hepato-protective activity of a drug should be based on its ability to reduce the injurious effect or to preserve the architecture and physiological functions of the liver disturbed by a hepatotoxin. Hepatoprotective drugs are those compounds, which mitigate the liver injury caused by hepatotoxic agents. Liver injury treatments are important issue of today’s research domain, because of many allopathic drugs and their toxic influence lead to liver damage. Modern treatment leads to serious adverse effects which eventually hepatic damage with symptoms include indigestion (constipation), fatigue, allergies and chemical sensitivities, jaundice, edema, body weight loss and neurological disorders. Further protective role of herbal drugs is not ignored because, herbal drugs are also acts by multiple pathways and shown full protection in liver disorders so there is a need to study different herbal drugs and their protective mechanism for liver disorders. Isolated active principles / secondary plant metabolites (SPMs) / phyto- pharmaceutical are to be treated like modern drugs and subjected to rigorous testing as required by the regulatory authorities. |
| Keywords: | - |
| Cite Article: | "Drug Induced Hepatotoxicity and Hepatoprotective Drugs : A Review", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 9, page no.351 - 375, September-2023, Available :http://www.ijsdr.org/papers/IJSDR2309058.pdf |
| Downloads: | 000338720 |
| Publication Details: | Published Paper ID: IJSDR2309058 Registration ID:208500 Published In: Volume 8 Issue 9, September-2023 DOI (Digital Object Identifier): Page No: 351 - 375 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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