IN-SILICO ANTI-INFLAMMATORY ACTIVITY AND QUALITATIVE BIOCHEMICAL ANALYSIS OF MOOLATHUKKU CHOORANAM - A SIDDHA MONOHERBAL FORMULATION

K Govindaraj , N S Prabhusiva , S Sundararajan

Keywords:Moolam,Hemarrhoids,Moolathukku chooranam,Anti-inflammatory activity.

ABSTRACT: Background :Siddha system of medicine is the indigenous system of medicine practiced in south India especially in Tamilnadu. Moolam (Hemorrhoids) is one of the disease out of 4448 diseases mentioned in Siddha literatures.Yugi Muni has described about Moolam in “Yugi Vaithiya Chinthamani’. Moolathukku Chooranam is a monoherbal drug indicated for Moolam which is mentioned in Gunapadam Mooligai Vakuppu. Aim: The aim of the study is to analyze the in-silico anti inflammatory potential and biochemical analysis of Moolathukku chooranam. Methodology: Binding of phytocomponents with the core amino acids (His70,Asp71, Ser72, Val91,Pro117, Ser119, Thr120, Pro121, Ser122, Thr124, Thr125) of the target by forming hydrogen bond will hinder the function of the inflammatory cytokine IL6 (Interleukin 6) with PDB – 1N26. These amino acid residues are functionally responsible for binding of substrate and inhibitors. Thereby phytocomponents which inhibit the target IL6 (Interleukin 6) may act as a potential therapeutic agent for management of inflammation Result: The study result concludes that Moolathukku chooranam has significant Anti- inflammatory activity.

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"IN-SILICO ANTI-INFLAMMATORY ACTIVITY AND QUALITATIVE BIOCHEMICAL ANALYSIS OF MOOLATHUKKU CHOORANAM - A SIDDHA MONOHERBAL FORMULATION", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.8, Issue 9, page no.577 - 580, September-2023, Available :https://ijsdr.org/papers/IJSDR2309084.pdf

Volume 8 Issue 9, September-2023

Pages : 577 - 580

Paper Reg. ID: IJSDR_208544

Published Paper Id: IJSDR2309084

Downloads: 000347361

Research Area: Medical Science

Country: Tirunelveli, Tamilnadu, India

Published Paper PDF: https://ijsdr.org/papers/IJSDR2309084

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR2309084

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

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