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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Diclofenac Sodium (NSAID) Proniosomal Formulation for Enhanced Transdermal Delivery |
| Authors Name: | Rajeev Kumar Chahar , Raj Kumar Mishra , Kamal Bani , Bhanu P. S. Sagar |
| Unique Id: | IJSDR2309122 |
| Published In: | Volume 8 Issue 9, September-2023 |
| Abstract: | The objective of the thesis was to assess proniosomes of DFS to increase its permeation through skin for enhanced transdermal drug delivery in systemic circulation avoiding hepatic first-pass metabolism. Results indicated that all the formulations were found to be smooth and spherical in shape and average particle size (17.52±1.54 to 25.23±1.02; size influenced by agitation). Drug loading efficacy (%) of proniosomes was 90.78±0.96 to 95.92±1.36. Entrapment efficacy was maximum for formulation R4. The in-vitro drug release study was performed in phosphate buffer solution at pH 7.2 and by changing the combination of different types of surfactants the % drug release were found in the range of 85.12±3.82, 80.46±2.54, 83.87±2.92, 79.12±2.62 and 76.25±2.80 for formulations R1, R2, R3, R4, R5 and R6 respectively. Finally, present study conclusively demonstrated that drugs having poor water solubility showed enhanced bioavailability by transdermal route via proniosomes. |
| Keywords: | Drug release, drug loading, entrapment, first pass metabolism, nanotechnology, niosomes, proniosomes, skin, surfactant, transdermal |
| Cite Article: | "Diclofenac Sodium (NSAID) Proniosomal Formulation for Enhanced Transdermal Delivery", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 9, page no.829 - 855, September-2023, Available :http://www.ijsdr.org/papers/IJSDR2309122.pdf |
| Downloads: | 000338719 |
| Publication Details: | Published Paper ID: IJSDR2309122 Registration ID:208664 Published In: Volume 8 Issue 9, September-2023 DOI (Digital Object Identifier): Page No: 829 - 855 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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