INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016
open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15
Formulation Development and Evaluation of Microspheres of Cefpodoxime Proxetil - A Broad Spectrum Cephalosporin with Short Half-life
Authors Name:
Shivani Mishra
, Raj Kumar Mishra , Fabiha Rahish , Bhanu P. S. Sagar
Unique Id:
IJSDR2310114
Published In:
Volume 8 Issue 10, October-2023
Abstract:
In present investigation, to develop mucoadhesive microsphere of cefpodoxime proxetil, it was first identified by characteristics infrared spectra and then it was subjected to melting point determination, partition coefficient determination and solubility analysis. After that the drug was analysed in UV spectrophotometer by constructing standard curve in 0.1 N HCl (pH-1.2). It was found that the drug was confirming all the pharmacopoeial standards with respect to melting point, partition coefficient, solubility, wavelength of maximum absorption (λmax) and the characteristics of IR spectra. Polymer used in formulation of microspheres, may interfere in the estimation of drug. The mp of cefpodoxime proxetil was found to be 1110C. The PC of cefpodoxime proxetil was found to be 5.1 (lipophilic). Formulations FC2 and FC4 follows zero order release kinetics with r2 value of 0.991, 0.998 respectively. From the study it is evident that promising controlled release mucoadhesive microspheres of cefpodoxime proxetil may be developed by solvent evaporation techniques by using polymers for reduced dosing frequency and better patient compliance therapy.
Keywords:
Bioadhesive, drug release, gastrointestinal tract, melting point determination, microspheres, lipophilic, partition coefficient, polymers, solubility.
Cite Article:
"Formulation Development and Evaluation of Microspheres of Cefpodoxime Proxetil - A Broad Spectrum Cephalosporin with Short Half-life", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 10, page no.718 - 739, October-2023, Available :http://www.ijsdr.org/papers/IJSDR2310114.pdf
Downloads:
000338720
Publication Details:
Published Paper ID: IJSDR2310114
Registration ID:208713
Published In: Volume 8 Issue 10, October-2023
DOI (Digital Object Identifier):
Page No: 718 - 739
Publisher: IJSDR | www.ijsdr.org
ISSN Number: 2455-2631
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