|
INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
Imp Links for Author
Imp Links for Reviewer
Research Area
Subscribe IJSDR
Visitor Counter
Copyright Infringement Claims
Indexing Partner
|
Published Paper Details
|
|
| Paper Title: | A NEW ROUTE FOR SCALABLE SYNTHESIS OF 3,5 Bis(hydroxymethyl)phenol AND THEIR DERIVATIVES |
| Authors Name: | Knv. Kiranmayi , Dr. S Shobha Rani |
| Unique Id: | IJSDR2311004 |
| Published In: | Volume 8 Issue 11, November-2023 |
| Abstract: | 3,5 bis(hydroxymethyl)phenol belong to the class polyphenols which is widely used for synthesis of complex nuclearity clusters and has clinical relevance in the treatment of allergies. It is a key organic compound widely used in the synthesis of various biologically active products, polymer chemistry and peptide chemistry. Mainly used in synthesis of poly(aryl ether)dendrimers and monodendrons and can also be used as an intermediate for synthesizing ligand and as a reagent for alkali metals. Many literature methods are available for the synthesis of 3,5 bis(hydroxymethyl)phenol using lithium aluminium hydride (LAH) as a reducing agent. But these procedures are not suitable for scaleup due to safety concerns of LAH, tedious workup procedures and difficultly in isolation of product. In this study, a simple and scalable approach for the synthesis of 3,5 bis(hydroxymethyl)phenol was proposed. Methyl ester of 5-hydroxy isophthalic acid was benzylated at the phenol group and reduced with sodium borohydride to obtain diol. The obtained benzylated compound was later debenzylated using Pd/C under H2 conditions for desired product. To study 3,5 bis(hydroxymethyl)phenol further, derivatives was made by methylation, reduction and bromination which yielded 3 derivatives. 3,5 bis(hydroxymethyl)phenol and the derivatives were analyzed using UV Visible spectroscopy, IR spectroscopy and NMR spectroscopy. |
| Keywords: | Keywords: 3,5 bis(hydroxymethyl)phenol, Scalable synthesis, Sodium borohydride, 5-hydroxy isophthalic acid, Key organic compound |
| Cite Article: | "A NEW ROUTE FOR SCALABLE SYNTHESIS OF 3,5 Bis(hydroxymethyl)phenol AND THEIR DERIVATIVES", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 11, page no.23 - 27, November-2023, Available :http://www.ijsdr.org/papers/IJSDR2311004.pdf |
| Downloads: | 000338719 |
| Publication Details: | Published Paper ID: IJSDR2311004 Registration ID:209137 Published In: Volume 8 Issue 11, November-2023 DOI (Digital Object Identifier): Page No: 23 - 27 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
|
Click Here to Download This Article |
|
| Article Preview | |
|
|
|
Major Indexing from www.ijsdr.org
| Google Scholar | ResearcherID Thomson Reuters | Mendeley : reference manager | Academia.edu |
| arXiv.org : cornell university library | Research Gate | CiteSeerX | DOAJ : Directory of Open Access Journals |
| DRJI | Index Copernicus International | Scribd | DocStoc |
Track Paper
Important Links
Conference Proposal
ISSN
 |
 |
DOI (A digital object identifier)
  Providing A digital object identifier by DOI How to GET DOI and Hard Copy Related |
Open Access License Policy
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
|
 |
 |
 |
Social Media
Indexing Partner |
|||
| Copyright © 2024 - All Rights Reserved - IJSDR | |||
Facebook Twitter Instagram LinkedIn