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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Formulation and invitro evaluation of aceclofenac sustained release matrix tablet |
| Authors Name: | Priyadarshisanjib Sahu , Dr. Sradhanjali Patra |
| Unique Id: | IJSDR2311015 |
| Published In: | Volume 8 Issue 11, November-2023 |
| Abstract: | Aceclofenac, a potent non-steroidal anti-inflammatory drug (NSAID), has garnered attention for its remarkable analgesic and anti-inflammatory properties. However, its short half-life necessitates frequent dosing, prompting the exploration of sustained-release formulations to extend therapeutic efficacy. This study focuses on the formulation of sustained-release matrix tablets for Aceclofenac via the direct compression technique. Key excipients, including hydroxypropyl methylcellulose (HPMC) variants (K4M, K15M, K100M), were selected to modulate drug release profiles. Formulation techniques encompassing direct compression were employed, followed by rigorous characterization involving drug content uniformity assessment, dissolution studies, release kinetics. The results obtained from these evaluations offer valuable insights into the effectiveness of the developed matrix tablet. The release kinetics of the formulated tablets exhibited a Higuchi model with a non-Fickian diffusion mechanism, indicating controlled and sustained drug release. This research presents a promising approach to enhance the therapeutic potential of Aceclofenac through sustained-release formulations, potentially reducing the frequency of administration and improving patient compliance. |
| Keywords: | Aceclofenac, sustained release tablet, HPMC, Direct compression |
| Cite Article: | "Formulation and invitro evaluation of aceclofenac sustained release matrix tablet", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 11, page no.86 - 91, November-2023, Available :http://www.ijsdr.org/papers/IJSDR2311015.pdf |
| Downloads: | 000338719 |
| Publication Details: | Published Paper ID: IJSDR2311015 Registration ID:209168 Published In: Volume 8 Issue 11, November-2023 DOI (Digital Object Identifier): Page No: 86 - 91 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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