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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | A Comprehensive Review: Revealing Curcumin`s Multifaceted Journey Through Various Cellular Pathways |
| Authors Name: | Sushil Kumar Mali , Sumit Kumar Gupta , Ram Prakash Yadav , Shivani Sharma |
| Unique Id: | IJSDR2311019 |
| Published In: | Volume 8 Issue 11, November-2023 |
| Abstract: | Curcumin, a polyphenolic derivative of turmeric, is a naturally occurring compound isolated from Curcuma longa that suppresses and inverts carcinogenesis via multifaceted molecular targets and has attracted a lot of interest due to its wide range of biological activities. This review explores the complex connections that curcumin has with important signaling networks as it travels via cellular pathways. Numerous in vitro and in vivo experimental models have also revealed that curcumin regulates several molecules in the cell signal transduction pathway including NF-κB, Akt, MAPK, p53, Nrf2, Notch-1, JAK/STAT, β-catenin, and AMPK. Curcumin shows promising therapeutic implications for a variety of illnesses, including cancer, neurological disorders, metabolic syndromes, and inflammation, due to its diverse modulatory actions and potential as a powerful medication in contemporary medicine which offers priceless insights into its pharmacological processes. To fully realize the medicinal potential of curcumin thorough investigation seeks to close the gap between basic science and practical application. This review article focuses on curcumin's potential in cancer therapy by modulating the WNT/β-catenin pathway, suppressing chronic inflammation and oxidative stress. Curcumin has been shown to downregulate this pathway by controlling tumor growth. In this article, we begin by evaluating its molecular targets and mechanism of action underlying curcumin's anticancer effects, including its modulation of cell signaling pathways, inhibition of tumor growth, and induction of apoptosis. |
| Keywords: | Curcumin, signaling pathways, WNT/β-catenin pathway, Apoptosis |
| Cite Article: | "A Comprehensive Review: Revealing Curcumin`s Multifaceted Journey Through Various Cellular Pathways", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 11, page no.114 - 127, November-2023, Available :http://www.ijsdr.org/papers/IJSDR2311019.pdf |
| Downloads: | 000338719 |
| Publication Details: | Published Paper ID: IJSDR2311019 Registration ID:209195 Published In: Volume 8 Issue 11, November-2023 DOI (Digital Object Identifier): Page No: 114 - 127 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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