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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Pharmacological Assessment of Cassia Occidentalis Leaves for Anti-Inflammatory and Wound Healing Properties |
| Authors Name: | Ritesh Rai , Sonia Bhatt , Amrita Singh , Vikash Kumar , Bhanu P. S. Sagar |
| Unique Id: | IJSDR2311030 |
| Published In: | Volume 8 Issue 11, November-2023 |
| Abstract: | In present research investigation, an attempt to conduct wound healing activity and anti-inflammatory investigation of Cassia occidentalis L. Cassia occidentalis L. plant was scientifically authenticated. PPMs and SPMs like anthraquinones, phenolics, flavanoids, terpenoids and saponins were present. Percolation method yielded MECOL extract (3.8% yield) and EECOL extract (4.32% yield). Further, chrysophanol was purified by IPTLC method (10.6% in MECOL extract). In toxicity assessment, no abnormal behaviour; no significant alterations in hematological parameters, modification in renal function and LFTs even at higher dose. No mortality was found and EECOL, MECOL and chrysophanol were found be non-toxic constituent even at 2000 mg/kg/b.wt. (possess wide safety margin). LD50 was found to be 1000 mg/kg b.w. (chrysophanol) and 1600 mg/kg b.w. (MECOL / EECOL). Chrysophanol MECOL, and EECOL Extract produced significant anti- inflammatory effects and edema inhibition was maximum with standard drug (35.97%) followed by Chrysophanol (32.4%), MECOL-B (31.78%) and EECOL-B (31.22%). Treatment with MECOL-B, EECOL-B extract and chrysophanol produced significant wound healing comparable to soframycin (p<0.01). Histology of MECOL, EECOL and Chrysophanol treated animals showed high rate of wound contraction, increased epithelialisation and regenerated tissue, and new blood vessel formation. Finally, much more elaborative phytochemical and pharmacological research work is proposed to endorse the findings of the present research work. |
| Keywords: | Anti-inflammatory, Chrysophanol, Cassia occidentalis, Kassaumdhi, percolation, Indomethacin, Carrageenan, physico-chemical analysis |
| Cite Article: | "Pharmacological Assessment of Cassia Occidentalis Leaves for Anti-Inflammatory and Wound Healing Properties", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 11, page no.196 - 207, November-2023, Available :http://www.ijsdr.org/papers/IJSDR2311030.pdf |
| Downloads: | 000338719 |
| Publication Details: | Published Paper ID: IJSDR2311030 Registration ID:209252 Published In: Volume 8 Issue 11, November-2023 DOI (Digital Object Identifier): Page No: 196 - 207 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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