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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Formulation Development and Evaluation of Microparticles of Pantoprazole |
| Authors Name: | Vaibhav Saxena , Raj Kumar Mishra , Amrita Singh , Bhanu P. S. Sagar |
| Unique Id: | IJSDR2311047 |
| Published In: | Volume 8 Issue 11, November-2023 |
| Abstract: | The present research investigation was undertaken with the objective to develop gastrointestinal drug delivery system of pantoprazole – a well known proton pump inhibitor and widely used in the treatment of gastric, duodenal ulcer and also in gastro-esophageal reflux disease (GERD), Zollinger-Ellison syndrome. A controlled release system for pantoprazole is designed to enhance the stability of the pantoprazole in stomach and to by-pass the stomach by making a gastro-resistant double walled microspheres drug delivery system. The formulations were developed consisting of double wall. The primary wall composed of mucoadhesive polymer like sodium CMC and a release controlling polymer sodium alginate. There were many batches formulated to optimize the formulation. The first batch was formulated without drug and observed to optimize the effect of stirring speed (500 rpm and 1000 rpm) for the preparation of the microspheres, the 500 rpm speed was selected due to reproducible result and a good particle size. The microspheres with the drug were analysed for the mucoadhesion and drug release. Five formulations were formulated like A1, A2, A3, A4 and A5. Formulation A5 contains the higher percentage of Sodium CMC showed the good drug entrapment efficiency, mucoadhesion, good drug release profile. Therefore it was selected as best formulation. Then the double walled microspheres was formulated by varying the concentration of Eudragit RS-100, there four formulations were formulated like formulation B1, B2, B3 and B4 which were analysed for particle size and drug release study, and finally formulation B1 shown good drug release among all the formulations analyzed. |
| Keywords: | Drug entrapment efficiency double walled microspheres, Gastro-esophageal reflux disease (GERD), mucoadhesion, mucoadhesive polymers, Eudragit, Sodium CMC. |
| Cite Article: | "Formulation Development and Evaluation of Microparticles of Pantoprazole", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 11, page no.315 - 325, November-2023, Available :http://www.ijsdr.org/papers/IJSDR2311047.pdf |
| Downloads: | 000338719 |
| Publication Details: | Published Paper ID: IJSDR2311047 Registration ID:209307 Published In: Volume 8 Issue 11, November-2023 DOI (Digital Object Identifier): Page No: 315 - 325 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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