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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | EVALUATION FOR NEPHROPROTECTIVE ACTIVITY OF ETHANOLIC EXTRACT OF DIOSPYROS MALABARICA GENTAMICIN -INDUCED NEPHROTOXICITY IN RATS |
| Authors Name: | Ch. Lochana , M. Ganesh Kumar , Dr. K. Atchuta kumar , N. Geetha Rani , B. Joshna |
| Unique Id: | IJSDR2312043 |
| Published In: | Volume 8 Issue 12, December-2023 |
| Abstract: | The present study reveals the acute toxicity of Diospyros malabarica fruit extract. No morbidity and mortality were observed at a higher dose of2000 mg/kg throughout the 14 days observation period. This acute study helps to predict that it does not contain any type of toxicity and it it full safe. Gentamicin induced nephroxicity is characterized by elevated levels of urea, creatinine, uric acid, total protein sodium and potassium in serum as well as urine urea and creatinine, severe proximal tubularnecrosis, renal failure were found to be significantly increased in rats treated with only gentamicin. Similar pattern of changes were also observed in this study following gentamicin treatment. DM supplemation to GM treated rats recorded decrement in levels of urea, creatinine, uric acid, total protein, sodium and potassium in serum and also in urine urea and creatinine. These observations indicate an improved in renal function. GM administration to control rats produced a typical pattern of nephrotoxicity which was manifestated by marked increase in serum BUN. DM supplementations to GM treated rats recorded decrement in levels of blood urea nitrogen in plasma. Histopathological results demonstrating structural changes n renal tissue of aminoglycoside antibiotics such as GM were reported by some researches. Histopathological view of renal sections in GM treated groups showed the degeneration, desquamation and necrosis in tubules, blood vessel congestion and swelling in glomerulus, as compared to control groups. Groups treated with GM + DM 200 mg/ kg showed tubular necrosis, necrotic changes, karyopicnosis, glomeruli showed mesangeal matrix expansion. Glomerular and tubular epithelial changes were considerably mild in groups treated with GM + 400 mg/kg and GM + 600 mg/kg i.e animal treated with DM 400 mg/kg showed mild glomerular mesangeal matrix expansion, mild tubular epithelial changes and no congestion in blood vessels while in case of animal treated with DM 600 mg/kg showed regeneration in tubular epithelial cells. Thus, morphological changes in kidneys were because of GM administration, but these changes tended to be mild in GM + DM treatment. |
| Keywords: | Nephroprotective Activity, Ethanolic Extract, Diospyros Malabarica, Gentamicin -Induced Nephrotoxicity |
| Cite Article: | "EVALUATION FOR NEPHROPROTECTIVE ACTIVITY OF ETHANOLIC EXTRACT OF DIOSPYROS MALABARICA GENTAMICIN -INDUCED NEPHROTOXICITY IN RATS", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 12, page no.308 - 316, December-2023, Available :http://www.ijsdr.org/papers/IJSDR2312043.pdf |
| Downloads: | 000338721 |
| Publication Details: | Published Paper ID: IJSDR2312043 Registration ID:209514 Published In: Volume 8 Issue 12, December-2023 DOI (Digital Object Identifier): Page No: 308 - 316 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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