Formulation and Evaluation of Bi-layered Tablet of Divalproex Sodium

Aditya Gupta , Dr. Nidhi Bais

Divalproex Sodium, Bi-layered Tablet, Antiepileptic, Patient acceptance, Immediate Release, Sustained Release

The objective of the current study was to develop bi-layered tablets of Divalproex Sodium containing immediate release layer and sustained release layer. Divalproex Sodium is considered as the most important antiepileptic drug and widely used for treatment of epilepsy and bi-polar disorders and prophylaxis of migraine. Both layer of divalproex sodium were prepared by wet granulation method. The immediate release layer was formulated by using sodium starch glycolate, croscarmellose sodium as super disintegrants. HPMC K4M and HPMC K100M polymer used to retard the drug release from sustained release layer in different proportion and combination. The optimized Immediate release layer (IF6) & sustained release layer (SF6) were selected to prepare Bi-layered tablet of Divalproex Sodium. In-vitro drug release studies were performed using USP type II apparatus (paddle method) in 900 ml of phosphate buffer pH 6.8 at 100 rpm. All the formulations were evaluated for post-compression parameters like hardness, weight variation, friability, thickness, disintegration time, drug content and in-vitro % drug release. The formulations were selected based on their disintegration time and in-vitro % drug release. The final results obtained showed that the disintegration time is 35.33 seconds and in-vitro % drug release of IRL 99.50 % & in-vitro % drug release of SRL 99.56%.

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"Formulation and Evaluation of Bi-layered Tablet of Divalproex Sodium ", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.8, Issue 12, page no.432 - 440, December-2023, Available :https://ijsdr.org/papers/IJSDR2312059.pdf

Volume 8 Issue 12, December-2023

Pages : 432 - 440

Paper Reg. ID: IJSDR_209569

Published Paper Id: IJSDR2312059

Downloads: 000347519

Research Area: Pharmacy

Country: Morena , Madhya Pradesh, India

Published Paper PDF: https://ijsdr.org/papers/IJSDR2312059

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR2312059

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJSDR(IJ Publication) Janvi Wave

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