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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Formulation and Evaluation of Combinational Liposomes of Biochanin-A and Docetaxel for Breast Cancer Treatment |
| Authors Name: | Ajay Kumar , Amrita Singh , Snehil Singh , Bhanu P. S. Sagar |
| Unique Id: | IJSDR2312071 |
| Published In: | Volume 8 Issue 12, December-2023 |
| Abstract: | The solubility study of Biochanin A (BCA) and Docetaxel (DTX) indicated that both drugs were poorly soluble in water but shown the better solubility in HBSE buffer. So, the HBSE buffer was chosen as vehicle since sufficient amount of drug dissolve in it, which is necessary to maintain sink conditions. The partition coefficient of BCA and DTX was found to be 3.42 and 4.38 respectively. The values clearly indicated that both the drugs are lipophilic and soluble in lipids and so both the drugs have been added to the lipid part during preparation of liposome. Various formulations of the combination of BCA and DTX were prepared by sonication method with different ratios of soya lecithin and cholesterol at different sonication speed. Entrapment efficiency of the F6 formulation of Biochanin A was very high (70.0±0.58) then F6 formulation of Docetaxel (69.9±0.96) because of high sonication speed. The effect of the soya lecithin and cholesterol ratio in the lipid components of vesicles on the entrapment efficiency of lipophilic drugs, Biochanin A and Docetaxel, the efficiency was increased with sonication speed and decreased with the ratio of phosphatidylcholine. Particle size of liposomes was measured by particle size analyzer and best size of liposome formulation vehicle was 202±0.66 nm of formulations F6. MTT assay for selected formulations were performed and it was found that combination liposomes were having better cytotoxic potential than the individual drugs (separate drugs / drugs alone). The difference was statistically significant. |
| Keywords: | Biochanin-A, cancer, cholesterol, cytotoxic potential, docetaxel, lipophilic, liposomes, nano-particles, phosphatidylcholine, sonication, soya lecithin |
| Cite Article: | "Formulation and Evaluation of Combinational Liposomes of Biochanin-A and Docetaxel for Breast Cancer Treatment", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 12, page no.530 - 543, December-2023, Available :http://www.ijsdr.org/papers/IJSDR2312071.pdf |
| Downloads: | 000338719 |
| Publication Details: | Published Paper ID: IJSDR2312071 Registration ID:209589 Published In: Volume 8 Issue 12, December-2023 DOI (Digital Object Identifier): Page No: 530 - 543 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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