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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Working memory deficit in stable patients of schizophrenia and its correlation with biochemical markers: A cross sectional study at tertiary care hospital in north India |
| Authors Name: | Dr Ravi Prakash Sharma , Dr Lalit Batra , Dr Suresh Gupta |
| Unique Id: | IJSDR2312104 |
| Published In: | Volume 8 Issue 12, December-2023 |
| Abstract: | Background: Little stress was paid on the status of cognition in stable or remission state in recent past. Deficiency of micronutrients such as vitamin B12, folate and calcium are often under recognized condition causing cognitive symptoms. Association of these biochemical parameters with working memory impairment in unknown which emphasize the management plan for cognitive domain. Aim: We investigated working memory deficit and its correlation with serum vitamin B12, serum folate and serum calcium in stable schizophrenic patients. Methods: Thirty-five schizophrenic patients stable on treatment after assessing with PANSS scale as per ICD 10 criteria and thirty-five controls were recruited free of neurological comorbidities. Working memory questionnaire was applied in Hindi language for assessment of working memory deficit. Results: Significantly high scores of total working memory (U= 58.5, p= 0.00), storage domain (U= 58.0, p= 0.00), attention domain (U= 85.5, p= 0.00) and executive domain (U= 92.0, p= 0.00) were obtained in schizophrenia group than control suggesting working memory deficit in stable schizophrenic patients. Mean serum vitamin B12 and folate level were significantly higher in control than schizophrenics. Significantly negative correlation of serum vitamin B12 with total working memory scores, storage domain, attention domain and executive domain and serum folate with only executive domain were detected. Correlation of serum calcium was found insignificant. Conclusion: Schizophrenic subjects still had significant daily routine problems due to working memory deficit even after treatment. Serum vitamin B12 and folate negatively correlated with working memory deficits and executive dysfunction respectively. Keywords: Working-memory, storage, attention, executive, folate, vitaminB12 |
| Keywords: | Working-memory, storage, attention, executive, folate, vitaminB12 |
| Cite Article: | "Working memory deficit in stable patients of schizophrenia and its correlation with biochemical markers: A cross sectional study at tertiary care hospital in north India", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 12, page no.806 - 813, December-2023, Available :http://www.ijsdr.org/papers/IJSDR2312104.pdf |
| Downloads: | 000338720 |
| Publication Details: | Published Paper ID: IJSDR2312104 Registration ID:209635 Published In: Volume 8 Issue 12, December-2023 DOI (Digital Object Identifier): Page No: 806 - 813 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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