|
INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
Imp Links for Author
Imp Links for Reviewer
Research Area
Subscribe IJSDR
Visitor Counter
Copyright Infringement Claims
Indexing Partner
|
Published Paper Details
|
|
| Paper Title: | A Study on the effect of different doses of pregabalin on the testis in adult male albino rat. |
| Authors Name: | Marwa Sayed Badawi |
| Unique Id: | IJSDR2312113 |
| Published In: | Volume 8 Issue 12, December-2023 |
| Abstract: | Background: Pregabalin (PGB) is an anti-convulsant drug that is indicated in epilepsy, neuropathic pain and anxiety. Pregabalin is an analogue to the neurotransmitter gamma amino butyric acid (GABA). Its main site of action is in the peripheral and central nervous systems. The present study aimed to evaluate the effect of different doses of pregabalin on the Testis in adult male rats. Methods: 30 male albino rats were divided into 3 groups with 10 rats in each group. Group I (control group). Group ІІ animals received pregabalin orally in a dose of 600 mg/kg/day for 4 weeks. Group ІІI animals received pregabalin orally in a dose of 1200 mg/kg/day for 4 weeks. At the end of the experiment, Blood samples were taken and concentrations of testosterone, FSH and LH were measured by Radioimmunoassay method. Then, the testes were processed for histopathological study. Results: The results showed that administration of PGB at a dose of 1200 mg/kg reduced serum testosterone level while it increased FSH and LH levels (p<0.05). It also caused a decrease in sperm motility, count and percent of viability and an increase in sperm abnormalities (p<0.05). Histological examination of the testes showed reduction in the number of spermatogenic and Leydig cells. Conclusion: PGB has toxic effects on the testes when given at a dose of 1200 mg/kg as indicated by decreased concentration of testosterone, increased FSH and LH levels, a decrease in sperm motility, count and percent of viability, an increase in sperm abnormalities and reduced number of spermatogenic and leydig cells. |
| Keywords: | Pregabalin; Testis; Histopathology; Testosterone; FSH; LH; Sperm parameters |
| Cite Article: | "A Study on the effect of different doses of pregabalin on the testis in adult male albino rat.", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 12, page no.860 - 867, December-2023, Available :http://www.ijsdr.org/papers/IJSDR2312113.pdf |
| Downloads: | 000338720 |
| Publication Details: | Published Paper ID: IJSDR2312113 Registration ID:209684 Published In: Volume 8 Issue 12, December-2023 DOI (Digital Object Identifier): Page No: 860 - 867 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
|
Click Here to Download This Article |
|
| Article Preview | |
|
|
|
Major Indexing from www.ijsdr.org
| Google Scholar | ResearcherID Thomson Reuters | Mendeley : reference manager | Academia.edu |
| arXiv.org : cornell university library | Research Gate | CiteSeerX | DOAJ : Directory of Open Access Journals |
| DRJI | Index Copernicus International | Scribd | DocStoc |
Track Paper
Important Links
Conference Proposal
ISSN
 |
 |
DOI (A digital object identifier)
  Providing A digital object identifier by DOI How to GET DOI and Hard Copy Related |
Open Access License Policy
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
|
 |
 |
 |
Social Media
Indexing Partner |
|||
| Copyright © 2024 - All Rights Reserved - IJSDR | |||
Facebook Twitter Instagram LinkedIn