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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | EFFICACY OF PROPHYLACTIC ONDANSETRON ON PREVENTION OF SPINAL ANAESTHESIA INDUCED HYPOTENSION DURING CAESARIAN DELIVERY; A RANDOMIZED CONTROLLED TRIAL |
| Authors Name: | Dr Pampanna R , Dr Anusha G Hiremath , Dr Pradnya Kothari |
| Unique Id: | IJSDR2401061 |
| Published In: | Volume 9 Issue 1, January-2024 |
| Abstract: | BACKGROUND: Ondansetron a 5HT3 receptor blocker known to block BJR, can be beneficial in attenuating the maternal hypotension and bradycardia when injected before SAB. We aimed to study efficacy of prophylactic ondansetron 8mg iv on prevention of spinal anaesthesia induced hypotension during caesarian delivery. METHODS: Prospective, Randomized, Double-blinded, Controlled study was conducted on 64 parturient with a single foetus posted for Elective caesarean section under spinal anaesthesia who were divided into 2 groups, Group A received IV normal saline, 5 min before SAB and Group B received IV inj. Ondansetron 8 mg, 5 min before SAB. Both groups were co-loaded with 10ml/kg of RL over 20 min. Patient’s SBP,DBP,MAP,HR, ECG,SpO2 were monitored every minute for first 10 minutes after intrathecal injection, 2-minute intervals for the next 10 minutes and at 5-minute intervals thereafter need of vasopressors and adverse effects, outcomes in terms of APGAR score at 1minute and 5 minute. Umbilical arterial blood gas values were assessed. RESULTS: Intraoperative incidence of hypotension and hence the need for rescue vasopressors was significantly high (P < 0.001) in group A (90.63%). The Systolic Blood Pressure (SBP) remained to be lower in the group A compared to the Group B attaining statistical significance from the fourth minute after the administration of spinal anaesthesia till the twelfth minute. Mean DBP and MAP was decreased more in group A at different time intervals. 12(37.5%) and 5(15.6%) of the patients in Group A and B were presented with IONV. 16(50%) and 6(18.8%) were presented with PONV in Group A and Group B respectively with p value of 0.013. There was no difference in foetal outcome between the groups. CONCLUSION: Prophylactic use of 8 mg ondansetron IV is effective in reducing the incidence of spinal anaesthesia-induced hypotension, PONV, requirement of vasopressor in parturient undergoing elective caesarean section under spinal anesthesia. |
| Keywords: | KEY WORDS: Caesarean section, ondansetron, hypotension, bezold‑jarisch reflex, ephedrine, phenylephrine. |
| Cite Article: | "EFFICACY OF PROPHYLACTIC ONDANSETRON ON PREVENTION OF SPINAL ANAESTHESIA INDUCED HYPOTENSION DURING CAESARIAN DELIVERY; A RANDOMIZED CONTROLLED TRIAL", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.9, Issue 1, page no.413 - 421, January-2024, Available :http://www.ijsdr.org/papers/IJSDR2401061.pdf |
| Downloads: | 000338719 |
| Publication Details: | Published Paper ID: IJSDR2401061 Registration ID:209864 Published In: Volume 9 Issue 1, January-2024 DOI (Digital Object Identifier): Page No: 413 - 421 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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