Naso pulmonary drug delivery system
D.Rama Brahma Reddy
, K. Malleswari , U.V. Prasanna
Naso-Pulmonary drug delivery, peptides and proteins, nose, nasal pulmonary, respiratory tract
Nasal drug delivery has received a great deal of attention as a convenient, reliable and promising method for the systemic administration of drugs. It is especially for those molecules which are ineffective orally and only effective if administered by injection. This is due to high vascularity, large surface area, the avoidance of hepatic first pass metabolism, gut wall metabolism and/or destruction in gastrointestinal tract. Since nasal mucosa offer several benefits for target delivery, a wide variety of therapeutic compounds may be administered intranasally for topical, systemic and central nervous system action. Many drug delivery devices for nasal application of liquid, semisolid and solid formulation are investigated to deliver the drugs to the treat most crisis CNS diseases (I . e. Parkinson’s disease, Alzheimer’s disease) because it requires rapid and/or specific targeting of drugs to the brain. It is well suitable for the delivery of biotechnological products like proteins, peptides, hormones, DNA plasmids for DNA vaccines to give enhanced bioavailability. Pulmonary drug delivery has attracted tremendous scientific and biomedical interest in recent years and has progress considerably within the context of local treatment for lung diseases, by virtue of enhanced local targeting and reduced systemic side effects with the administration of minute drug dosages. The present review is an attempt to provide some information concerning naso-pulmonary drug delivery system such as advantages, disadvantages, mechanism of drug absorption, anatomy of nasal cavity and respiratory tract, factors affecting nasal drug absorption, dosage form, novel drug formulations and recent advancement of nasal delivery system.
"Naso pulmonary drug delivery system", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.9, Issue 2, page no.184 - 189, February-2024, Available :https://ijsdr.org/papers/IJSDR2402027.pdf
Volume 9
Issue 2,
February-2024
Pages : 184 - 189
Paper Reg. ID: IJSDR_209996
Published Paper Id: IJSDR2402027
Downloads: 000347592
Research Area: Pharmacy
Country: -, -, India
ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: IJSDR(IJ Publication) Janvi Wave
