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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Protective effect of Helicteres isora in paclitaxel induced neuropathic pain in experimental animals |
| Authors Name: | Mr. Rehan M. Maniyar , Miss. Chaitali M. Diwane |
| Unique Id: | IJSDR2402050 |
| Published In: | Volume 9 Issue 2, February-2024 |
| Abstract: | Any abnormality in your body or a part of it will make you feel pain, which is an unpleasant experience. Depending on where it originates from, pain can be either physical or mental. There are several basic medicines that demonstrate their pharmacological efficacy for nociceptive activity. Nociception is the process of learning and processing noxious stimuli, and it describes the intensity of discomfort in the abdomen, which can be acute or persistent. It is a new approach with a low analgesic success rate. Rosemerinic Acid, which is present in H. isora and has been shown to be effective in treating neuropathy illnesses. The Sterculiaceae family includes the large tropical tree and shrub genera Helicteresisora L. The plant has been demonstrated to possess anti-inflammatory, hepatoprotective, anticancer, antidiarrheal, antibacterial, antiviral, and analgesic effects.During phytochemical screening, steroids, proteins, tannin and phenolic compounds,anthraquinon glycosides, and carbohydrates were found. In several animal models, such as the hot plate, tail flick, tail clip, cold pain, filament pain, tail immersion technique, acetic acid induced writhing test, and formalin induced writhing test, a number of synthetic and plant-based analgesics are being examined for efficacy and potency. By merely evaluating plant extracts using any of the models stated, many plant extracts have been shown to be analgesic; however, the current study is based on the detailed functioning principle and constructional detail of all the many models typically available in pharmacology laboratories. |
| Keywords: | H.isora, Nociceptive activity, Hot plate, Sterculiaceae. |
| Cite Article: | "Protective effect of Helicteres isora in paclitaxel induced neuropathic pain in experimental animals", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.9, Issue 2, page no.347 - 352, February-2024, Available :http://www.ijsdr.org/papers/IJSDR2402050.pdf |
| Downloads: | 000338719 |
| Publication Details: | Published Paper ID: IJSDR2402050 Registration ID:210102 Published In: Volume 9 Issue 2, February-2024 DOI (Digital Object Identifier): Page No: 347 - 352 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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