Recent advances in the chemistry and biology of naturally occurring antibiotics

Mr. Mane Shantanu Rohidas , Ms. Dadewad Swapnali Sanjiv , Mr. Shinde Gopal Vinayak , Ms. Ingale Monika Balaji

medicines, natural products, synthesis, structure–property relationship, and antibiotics

Ever since the world-shaping discovery of penicillin, nature's molecular diversity has been extensively screened for new medications and lead compounds in drug discovery. Antibiotics markets are huge and the need for new classes of antibiotics is great, but the risks give investors pause. The search for agents intended to combat infectious diseases has been of particular interest and has enjoyed a high degree of success. Indeed, the history of antibiotics is marked with impressive discoveries and drug-development stories, the overwhelming majority of which have their origin in natural products. Chemistry, and in particular chemical synthesis, has played a major role in bringing naturally occurring antibiotics and their derivatives to the clinic, and no doubt these disciplines will continue to be key enabling technologies. In this review article, we highlight a number of recent discoveries and advances in the chemistry, biology, and medicine of naturally occurring antibiotics, with particular emphasis on total synthesis, analogue design, and biological evaluation of molecules with novel mechanisms of action.

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"Recent advances in the chemistry and biology of naturally occurring antibiotics", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.9, Issue 2, page no.576 - 587, February-2024, Available :https://ijsdr.org/papers/IJSDR2402089.pdf

Volume 9 Issue 2, February-2024

Pages : 576 - 587

Paper Reg. ID: IJSDR_210193

Published Paper Id: IJSDR2402089

Downloads: 000347276

Research Area: Pharmacy

Country: Latur, Maharashtra, India

Published Paper PDF: https://ijsdr.org/papers/IJSDR2402089

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR2402089

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJSDR(IJ Publication) Janvi Wave

This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition