Design and development of polymeric microspheres loaded with model drug to provide sustained-release
Polymeric microspheres, mucoadhesive microspheres, spray drying method, metformin, controlled release.
Introduction: Diabetes is defined as a state of hyperglycemia in either fasting or postprandial states. The chronic hyperglycemia of diabetes mellitus (DM) is associated with end-organ damage, dysfunction, and failure in organs and tissues including the retina, kidney, nerves, heart, and blood vessels. Microspheres constitute an important part of particulate drug delivery systems by their small size and efficient drug entrapment capacity, deliver the therapeutic amount of the drug to the proper site in the body and then maintain, the desired drug concentration. In the present studies, it was planned to develop gastroretentive mucoadhesive microspheres of metformin by spray drying technique. Material and methods: The selection of the excipients and process was done by pre-optimization studies and for the final batch formulation optimization studies were performed. From the pre-optimization and optimization studies, it was concluded that the spray drying process is the most suitable process for the proposed formulation, and the more suitable excipients are Eudragit RSPO and HPMC K4M. The process parameters were also selected for drying rate and temperature. The selection of response variables was also done from the results of pre-optimization studies such as particle size, entrapment efficiency, and in-vitro drug release. Result and Discussion: The optimized batch's in-vitro drug release research revealed consistent drug release for up to 3 hours and mucoadhesion for up to 5 hours. The optimized mucoadhesive microspheres' micrometric characteristics, including bulk density, tapped density, compressibility index, Hausner ratio, and angle of repose, were found to be 0.16 g/cm3, 0.14 g/cm3, 10.1%, and 35.1°, respectively. The entrapment efficiency was found to be 69.4%. The image of SEM confirmed that microspheres were developed in regular size with the loading of the drug. Conclusion: The formulated polymeric microspheres containing metformin helped to improve the oral bioavailability of the drug and controlled its release rate, which lowers the frequency of dose and is beneficial for long-term treatment in the case of diabetes.
"Design and development of polymeric microspheres loaded with model drug to provide sustained-release", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.9, Issue 2, page no.876 - 884, February-2024, Available :https://ijsdr.org/papers/IJSDR2402127.pdf
Volume 9
Issue 2,
February-2024
Pages : 876 - 884
Paper Reg. ID: IJSDR_210402
Published Paper Id: IJSDR2402127
Downloads: 000347242
Research Area: Other
Country: -, -, India
ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: IJSDR(IJ Publication) Janvi Wave
