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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Enhanced Bilayered Tablet Formulation Of Ursodeoxycholic acid And PropylThiouracil :A Review |
| Authors Name: | Dharani Priya .B , Chockalingam.PL , Manasadevi.M , Harithra.SP |
| Unique Id: | IJSDR2404078 |
| Published In: | Volume 9 Issue 4, April-2024 |
| Abstract: | This study aims to create and evaluate a bilayer tablet formulation that contains ursodeoxycholic acid (UDCA) and propylthiouracil (PTU) for the treatment of hepatobiliary diseases and hyperthyroidism. PTU, which makes up the first layer, is intended to provide medication to treat hyperthyroidism instantly. Sustained release is provided by the second layer, which contains UDCA, to promote liver function and lessen the negative effects of PTU treatment. To achieve drug content homogeneity, hardness, disintegration, and dissolving characteristics, different formulation parameters were tuned. According to in vitro drug release investigations, each medicine on the bilayer tablet showed unique release patterns, guaranteeing its therapeutic efficacy and reducing the possibility of drug-drug interactions. Research on in vitro drug release has shown that propylthiouracil and ursodeoxycholic acid have both regulated and prolonged release characteristics. These findings may have advantages for patient compliance and therapeutic efficacy. For the concurrent treatment of hyperthyroidism and hepatobiliary diseases, the bilayered tablet containing PTU and UDCA offers a promising dose form. To confirm its effectiveness and safety for use in patients, more research is necessary, including in vivo investigations and clinical trials. When used in conjunction with other medical disorders, this novel formulation may lead to better treatment results and increased patient compliance. |
| Keywords: | UDCA, PTU, Immediate release, Sustained release |
| Cite Article: | "Enhanced Bilayered Tablet Formulation Of Ursodeoxycholic acid And PropylThiouracil :A Review", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.9, Issue 4, page no.564 - 573, April-2024, Available :http://www.ijsdr.org/papers/IJSDR2404078.pdf |
| Downloads: | 000338171 |
| Publication Details: | Published Paper ID: IJSDR2404078 Registration ID:210716 Published In: Volume 9 Issue 4, April-2024 DOI (Digital Object Identifier): Page No: 564 - 573 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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