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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Alzheimer`s Disease: A Comprehensive Review of Pathophysiology, Diagnosis, Treatment, and Caregiver Support Strategies |
| Authors Name: | K.R.KAMALESH , Dr.P.AMUDHA |
| Unique Id: | IJSDR2404149 |
| Published In: | Volume 9 Issue 4, April-2024 |
| Abstract: | Alzheimer's disease (AD) is a progressive neurological disorder characterized by cognitive decline and neurodegeneration, posing significant challenges to individuals, families, and healthcare systems globally. Since its initial identification by Dr. Alois Alzheimer in 1906, AD has emerged as a major public health concern due to its increasing prevalence with aging populations. This review provides a comprehensive examination of AD, encompassing its pathophysiology, etiology, diagnostic modalities, treatment strategies, and caregiver support. The pathophysiological mechanisms underlying AD involve intricate interactions among amyloid-beta plaques, tau protein pathology, neuroinflammation, synaptic dysfunction, mitochondrial dysfunction, excitotoxicity, and vascular factors. Genetic, environmental, and lifestyle factors contribute to the etiology of AD, with biomarkers and neuroimaging techniques offering promising avenues for early detection and intervention. Treatment strategies encompass pharmacological and non-pharmacological approaches aimed at symptom management and enhancing quality of life. Caregiver support and management are essential components of AD care, emphasizing education, respite care, support groups, counseling, legal and financial planning, technology-based support, and access to community resources. While pharmacological options offer symptom relief, ongoing research aims to develop novel therapeutic approaches targeting underlying disease mechanisms. Collaborative efforts among researchers, healthcare professionals, caregivers, policymakers, and communities are crucial for addressing the multifaceted challenges posed by AD in the 21st century. |
| Keywords: | Alzheimer's disease, neurodegeneration, dementia, diagnosis, treatment |
| Cite Article: | "Alzheimer`s Disease: A Comprehensive Review of Pathophysiology, Diagnosis, Treatment, and Caregiver Support Strategies", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.9, Issue 4, page no.1047 - 1052, April-2024, Available :http://www.ijsdr.org/papers/IJSDR2404149.pdf |
| Downloads: | 000338174 |
| Publication Details: | Published Paper ID: IJSDR2404149 Registration ID:210897 Published In: Volume 9 Issue 4, April-2024 DOI (Digital Object Identifier): Page No: 1047 - 1052 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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