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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | FORMULATION AND EVALUATION OF FAST DISSOLVING TABLET OF DAPAGLIFLOZIN |
| Authors Name: | Kajal More , Amreen Khan , Umesh Atneria , Dr. Neeraj Sharma , Dr. Dharmendra Solanki |
| Unique Id: | IJSDR2404215 |
| Published In: | Volume 9 Issue 4, April-2024 |
| Abstract: | The present research work envisages the applicability of superdisintegrants such as crospovidone and croscarmellose sodium in the design and development of fast dissolving formulation of Dapagliflozin by manual experiments. In the present work solubility of drug was enhanced by using inclusion complex. The inclusion complex of drug: β-cyclodextrin was prepared in different ratios by physical mixture method. The direct compression method was used to formulate and evaluate fast dissolving tablet of dapagliflozin. The prepared formulations were evaluated for precompression and post-compression studies. The increased concentration of the superdisintegrants enhanced the porosity of the tablet, due to which it reduced the disintegration time and wetting time and maximum drug release in 30 minutes. From all the results it is concluded that formulation FD6 containing crospovidone was found to be the best formulation in terms of flow property, disintegration time, wetting time, drug content and maximum percentage drug release. It was observed that formulation FD6 shown rapid disintegration time (30.5 sec), wetting time (30.1 sec) and percentage cumulative drug release 98.8% within 30 minutes. |
| Keywords: | Dapagliflozin, fast dissolving tablets, bioavailability, glycaemic, superdisintegrant |
| Cite Article: | "FORMULATION AND EVALUATION OF FAST DISSOLVING TABLET OF DAPAGLIFLOZIN", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.9, Issue 4, page no.1466 - 1472, April-2024, Available :http://www.ijsdr.org/papers/IJSDR2404215.pdf |
| Downloads: | 000338174 |
| Publication Details: | Published Paper ID: IJSDR2404215 Registration ID:211122 Published In: Volume 9 Issue 4, April-2024 DOI (Digital Object Identifier): Page No: 1466 - 1472 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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