PHYTOCHEMICAL AND ANTITUSSIVE INVESTIGATION OF BARK EXTRACTS OF ACACIA NILOTICA

Madhu Krishn Kumar , Harshit Singh , Balasubramanium Arumugam , N. K. sahu

Antitussive activity, Acacianilotica, Acacia bark, qualitative phytochemical analysis, plant extracts, cough suppressant activity, flavonoids

The main objective of present work is phytochemical and antitussive investigation of bark Extracts of Acacia Nilotica. Antitussives are remedies that alleviate coughing. Some antitussives work by soothing irritability (respiratory demulcents); others are claimed to relieve coughs at source, by removing congestive mucus or other mobile provocations (expectorants). Although the centrally acting opioids still remain the antitussive drug of choice for decades, they possess side effects such as sedation and gastrointestinal symptoms. The ethyl acetate and methanolic extracts of the bark of Acacia nilotica. were evaluated for antitussive action in mice using ammonium liquor induced cough and sulfur dioxide induced cough models at two different dose levels (250 and 500 mg/kg, po). The results indicate that the bark extract of Acacianilotica demonstrated antitussive effect in in vivo experimental models by prolonging the latency period of coughing and also reducing the frequency of coughing bouts in mice. The dose of 500 mg/kg of the methanolic extract was able to suppress the coughing bouts comparable to the standard drug codeine phosphate in the both the experimental models.

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"PHYTOCHEMICAL AND ANTITUSSIVE INVESTIGATION OF BARK EXTRACTS OF ACACIA NILOTICA", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.10, Issue 1, page no.a797-a811, January-2025, Available :https://ijsdr.org/papers/IJSDR2501083.pdf

Volume 10 Issue 1, January-2025

Pages : a797-a811

Paper Reg. ID: IJSDR_300265

Published Paper Id: IJSDR2501083

Downloads: 000347461

Research Area: Science and Technology

Country: -, -, India

Published Paper PDF: https://ijsdr.org/papers/IJSDR2501083

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR2501083

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

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