A Study of Hydroxamic Acids and their Complexes and their Biological Activity and Therapeutic Values Especially as Anticancer Medicine.
Dr. Aftab Ahmad Sulaiman
, Md. Mobashshir Sulaiman
Key words: Hydroxamic Acids, Hydroxamic Acids Complexes with Transition Metals like NBHA, HDAC etc.
Abstract
Hydroxamic acids are versatile ligands that can coordinate to metal ions, forming stable complexes. They have been extensively studied for their potential as Anticancer agents, particularly as histone deacetylase (HDAC) inhibitors and many more as Antibacterial, Antiviral and Antifungal.
Current paper is on various aspects of synthesis, structure and property of Ni and Pt metals complexes vs biological property. Hydroxamic acid has better attachment with Platinum metals group than others ligands on cancer therapy. We have used and demonstrated mechanism on biological activity and IR based stability of the complexes and mechanism of hydroxamic acid complexes on HDAC enzyme, binding to DNA and induce crosslinking of the complex by various justification. Further more research is indeed needed to overcome the shortcomings on hydroxamic acid Pt. metal complexes vs biological activity.
Hydroxamic acid derivatives and their complexes shows various therapeutic values against all of them which has well tolerable Efficacy. Efficacy of o/m/p-NBHA and other hydroxamic acids and their complexes have following characteristics which has high affinity for metal ions, strong chelating ability, selective inhibition of enzymes, antimicrobial activity against various pathogens, environmental compatibility and subsequently Safety in human.
Ongoing research on NBHA for more biological activities are needed to fully understand their potentiality. In this paper we have emphasised and enhances the hydroxamic acid with Pt. group transition metal complexes as biological activity and therapeutic values on antibacterial, antifungal, antiviral and anticancer. We have gone through the previous references.
Key words: Hydroxamic Acids, Hydroxamic Acids Complexes with Transition Metals like NBHA, HDAC etc.
"A Study of Hydroxamic Acids and their Complexes and their Biological Activity and Therapeutic Values Especially as Anticancer Medicine.", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.10, Issue 9, page no.b263-b277, September-2025, Available :https://ijsdr.org/papers/IJSDR2502133.pdf
Volume 10
Issue 9,
September-2025
Pages : b263-b277
Paper Reg. ID: IJSDR_300590
Published Paper Id: IJSDR2502133
Downloads: 00090
Research Area: Chemistry All
Country: MUZAFFARPUR, BIHAR, India
ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: IJSDR(IJ Publication) Janvi Wave
