Effect of Aqueous DMSO Solvent on the Hydrolysis Rate and Mechanism of a Biologically Active Ester Methylpicolinate

Shalini Kumari , D. K. Verma , Prahlad Kumar , Rajesh Kumar , Rachana Rani

Transition state theory, rate constant, Methylpicolinate, DMSO, Iso-composition activation energy, Iso-dielectric activation energy and solvation number

The kinetic study of hydrolysis of Methylpicolinate in an aqueous DMSO solvent mixture was conducted conductometrically to unravel the influence of solvent composition on reaction dynamics. The reaction was examined at four different temperatures—200C, 250C, 300C, and 350C while systematically varying the solvent proportion from 10% to 60%. Interestingly, the reaction rate consistently declined as the solvent composition increased across all temperature ranges. To gain deeper insight into the solvent effect on reaction kinetics and mechanism, key activation parameters were evaluated. Iso-composition activation energy, Iso-dielectric activation energy and various thermodynamic parameters were analyzed to provide a broader perspective on the reaction mechanism. Transition state theory drives thermodynamic approach of reaction rate and rate constant is expressed in terms of thermodynamic parameters. Kinetic study was also done in terms of water concentration.

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"Effect of Aqueous DMSO Solvent on the Hydrolysis Rate and Mechanism of a Biologically Active Ester Methylpicolinate", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.10, Issue 3, page no.a812-a818, March-2025, Available :https://ijsdr.org/papers/IJSDR2503090.pdf

Volume 10 Issue 3, March-2025

Pages : a812-a818

Paper Reg. ID: IJSDR_300924

Published Paper Id: IJSDR2503090

Downloads: 000319

Research Area: Chemistry All

Country: Vaishali, Bihar, India

Published Paper PDF: https://ijsdr.org/papers/IJSDR2503090

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR2503090

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJSDR(IJ Publication) Janvi Wave

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