Coenzyme Q10 Supplementation in Poor Ovarian Response and Diminished Ovarian Reserve: A Mitochondrial-targeted Strategy to Optimize Assisted Reproductive Technologies Outcome
Coenzyme Q10, Poor ovarian response, Diminished ovarian reserve, Assisted reproductive technologies, Female infertility
Abstract
Poor ovarian response (POR) and diminished ovarian reserve (DOR) are major contributors to suboptimal outcomes in assisted reproductive technologies (ART), which are often associated with reduced oocyte yield, lower fertilization rates, and diminished embryo quality. Emerging evidence has identified mitochondrial dysfunction and oxidative stress as central mechanisms underlying ovarian aging, thereby prompting interest in antioxidant-based therapeutic strategies. Coenzyme Q10 (CoQ10), a naturally occurring mitochondrial cofactor and potent antioxidant, plays a critical role in cellular energy production and the maintenance of redox homeostasis within ovarian cells. Preclinical and clinical studies suggest that CoQ10 supplementation improves mitochondrial efficiency, reduces reactive oxygen species (ROS), and enhances granulosa cell function, thereby collectively supporting oocyte competence and embryonic development.
Multiple randomized controlled trials and meta-analyses have demonstrated that CoQ10 pretreatment in women with POR and DOR significantly improves ovarian response, the number of mature oocytes retrieved, embryo quality, and clinical pregnancy rates. Doses ranging from 600 to 1200 mg daily for 8 to 12 weeks have been found to be effective, with minimal reported side effects. Compared to other adjunct therapies, such as DHEA and growth hormone, CoQ10 has shown superior efficacy in improving key ART outcomes, while maintaining a favorable safety profile.
Although further research is needed to standardize dosing regimens and to confirm effects on live birth rates and miscarriage rates, current evidence supports the clinical utility of CoQ10 as a safe and effective adjunct therapy for ovarian stimulation protocols. Its integration into ART practice represents a promising approach to optimizing outcomes in women with compromised ovarian reserve.
"Coenzyme Q10 Supplementation in Poor Ovarian Response and Diminished Ovarian Reserve: A Mitochondrial-targeted Strategy to Optimize Assisted Reproductive Technologies Outcome", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.10, Issue 9, page no.a246-a254, September-2025, Available :https://ijsdr.org/papers/IJSDR2509032.pdf
Volume 10
Issue 9,
September-2025
Pages : a246-a254
Paper Reg. ID: IJSDR_304808
Published Paper Id: IJSDR2509032
Downloads: 000119
Research Area: Humanities All
Country: Sultanpur, Uttar Pradesh, India
ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: IJSDR(IJ Publication) Janvi Wave
