Fecal Microbiota Transplantation: A Comprehensive Review of Clinical Applications, Mechanisms, Safety, and Future Directions

Shweta Macknight , Ms. Ankush Yadav , Mr. Azim Khan

Keywords: Fecal Microbiota Transplantation, FMT, Clostridioides difficile infection, gut microbiome, dysbiosis, clinical applications, safety, ethics, future directions

Abstract Fecal Microbiota Transplantation (FMT) is a therapeutic procedure involving the transfer of fecal material from a healthy donor into the gastrointestinal tract of a recipient. Initially recognized for its remarkable efficacy in treating recurrent Clostridioides difficile infection (CDI), FMT has gained significant interest for its potential beyond this indication. This review explores the underlying mechanisms of FMT, its established and emerging clinical applications, the current landscape of donor screening and administration methods, critical safety and ethical considerations, and the promising future directions of this evolving therapy. While highly effective for recurrent CDI, the application of FMT to other complex conditions like inflammatory bowel disease, irritable bowel syndrome, and metabolic disorders remains investigational, highlighting the need for further rigorous research and standardization.

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"Fecal Microbiota Transplantation: A Comprehensive Review of Clinical Applications, Mechanisms, Safety, and Future Directions", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.10, Issue 9, page no.a266-a271, September-2025, Available :https://ijsdr.org/papers/IJSDR2509035.pdf

Volume 10 Issue 9, September-2025

Pages : a266-a271

Paper Reg. ID: IJSDR_304839

Published Paper Id: IJSDR2509035

Downloads: 00099

Research Area: Humanities All

Country: Kasna, UTTAR PRADESH, India

Published Paper PDF: https://ijsdr.org/papers/IJSDR2509035

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR2509035

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJSDR(IJ Publication) Janvi Wave

This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition