OPTIMIZATION OF FERMENTATION PARAMETERS FOR ENHANCED PRODUCTION OF ANTIFUNGAL METABOLITES FROM ASPERGILLUS TERREUS AGAINST MUCORALEAN FUNGI

Tamanna Tandon , Dr. Pranay Jain

Optimization, Aspergillus terreus, Fermentation, Antifungal metabolite

The parameter to be employed for optimization is one of the core components of the microbial production system. The right physiological conditions are provided by an optimal growth environment, which enhances a chosen strain's capacity to produce antimicrobial compounds. Numerous physical elements, such as temperature, pH, inoculum size as well as nutritional variables, such as growth medium and sources of carbon and nitrogen, affect the generation and efficacy of bioactive chemicals. Various fermentation parameters, including the fermentation medium, incubation temperature, pH, and carbon and nitrogen sources, were optimized in order to achieve the best possible anti-mucorales metabolite production through fermentation by the endophytic fungi Aspergillus terreus. The maximum production of the antifungal metabolites by A. terreus strain was achieved in Potato dextrose broth medium supplemented with glucose (2%) as carbon and ammonium sulphate (2%) as nitrogen source. Further process parameters, like incubation temperature at 35 ℃, pH-6, found to be optimum for the maximal production of anti Mucorales metabolites.

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" OPTIMIZATION OF FERMENTATION PARAMETERS FOR ENHANCED PRODUCTION OF ANTIFUNGAL METABOLITES FROM ASPERGILLUS TERREUS AGAINST MUCORALEAN FUNGI", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.10, Issue 9, page no.a364-a378, September-2025, Available :https://ijsdr.org/papers/IJSDR2509046.pdf

Volume 10 Issue 9, September-2025

Pages : a364-a378

Paper Reg. ID: IJSDR_304877

Published Paper Id: IJSDR2509046

Downloads: 00087

Research Area: Life Sciences All

Country: Kurukshetra , Haryana , India

Published Paper PDF: https://ijsdr.org/papers/IJSDR2509046

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR2509046

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

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